Genetic polymorphisms in alcohol metabolizing enzyme and alcohol-induced health effects.

酒精代谢酶的遗传多态性和酒精引起的健康影响。

• 批准号: 07670414
• 负责人: YAMADA Yuichi
• 金额: $ 1.41万
• 依托单位: Department of Hygiene, Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670414/
• 关键词: cytochrome P450-2E1; genotype; Japanese; alcohol; bood pressure; serum uric acid; P4502El; hepatic enzymes; serum lipids; uric acid

Three-hundred-and-sixty-seven unrelated Japanese male workers aged between 36 and 61 years were analyzed for the genotypes of cytochrome P450 2E1 (CYP2E1), and the association with alcohol-related health effects including blood pressure (BP) elevation. Homozygous for the cl (wild) gene was found in 204 men (55%), homozygous for the c2 (variant) gene in 17 (5%), and heterozygous in 146 (40%). Arithmetic means of alcohol consumed per week in the genotypes of cl/cl, cl/c2 and c2/c2 were 218,257 and 211g, respectively, and were not statistically different. BP was elevated with the increase in alcohol consumption, and was significantly higher in the c2/c2 genotype than in the other genotypes among the subjects consuming 200g or more of alcohol per week. Serum uric acid did not correlate with alcohol consumption in the whole subjects, but it was also higher in drinkers having the c2/c2 genotype. Although the number of subjects was too small for a definite conclusion to be drawn, these results suggest to some extent that Japanese men having the c2/c2 genotype of CYP2E1 are more sensitive to the pressor effect of alcohol. Further studies are required to confirm this. Key words : alcohol, blood pressure, cytochrome P450 2E1, genotype, Japanese.

研究人员分析了367名年龄在36岁至61岁之间的无血缘关系的日本男性工人的细胞色素P450 2E1 （CYP2E1）基因型，以及其与酒精相关的健康影响（包括血压升高）的关系。cl（野生）基因纯合子204例（55%），c2（变异）基因纯合子17例（5%），杂合子146例（40%）。在基因型cl/cl、cl/c2和c2/c2中，每周饮酒量的算术平均值分别为218,257 g和211g，无统计学差异。血压随饮酒量的增加而升高，在每周饮酒量为200g或更多的受试者中，c2/c2基因型的血压明显高于其他基因型。在所有受试者中，血清尿酸与饮酒无关，但具有c2/c2基因型的饮酒者血清尿酸也较高。虽然受试者数量太少，无法得出明确的结论，但这些结果在一定程度上表明，具有CYP2E1的c2/c2基因型的日本男性对酒精的升压作用更敏感。需要进一步的研究来证实这一点。关键词：酒精，血压，细胞色素P450 2E1，基因型，日本人

项目成果

Yamada et al.: "Genotype of cytochrome P450 2E1 and alcohol-related blood pressure elevation in Japanese men" Blood Pressure. (in press).

Yamada 等人：“日本男性细胞色素 P450 2E1 的基因型和酒精相关的血压升高”血压。

Yamata et al.: "Genotype of cytochrome P450 2E1 and alcohol-related blood pressure elevation in Japanese men" Blood Pressure. 6. 112-116 (1997)

Yamata 等人：“日本男性细胞色素 P450 2E1 的基因型和酒精相关的血压升高”血压。

Tanaka et al.: "Genetic polymorphisms in alcohol metabolizing enzymes as related to sensitivity to alcohol-induced health effects." Environmental Health and Preventive Medicine. 1. 193-200 (1997)

Tanaka 等人：“酒精代谢酶的基因多态性与对酒精引起的健康影响的敏感性有关。”

Tanaka et al.: "Genetic polymorphisms in alcohol metabolizing enzymes as related to sensitivity to alcohol-induced health effects" Environmental Health and Preventive Medicine. 1. 193-200 (1997)

Tanaka 等人：“酒精代谢酶的基因多态性与对酒精引起的健康影响的敏感性有关”环境健康和预防医学。

Yamada et al.: "Genotyple of cytochrome P450 2E1 and alcohol-related blood pressure elevation in Japanese men" Blood Pressure. 6. 112-116 (1997)

Yamada 等人：“日本男性细胞色素 P450 2E1 的基因型和酒精相关的血压升高”血压。