Identification of a new apoptotic pathway of radiation-induced apoptosis of human peripheral lymphocytes

辐射诱导人外周淋巴细胞凋亡新途径的鉴定

• 批准号: 18591382
• 负责人: OGAWA Yasuhiro
• 金额: $ 2.49万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591382/
• 关键词: lymphocyte; apoptosis; mitochondria; lysosome; radiotherapy; 放射線抵抗性; 放射線感受性; 放射線治療; 放射線増感剤; 過酸化水素

Using a currently used linear accelerator we intended to inactivate peroxidase/catalase in a topical tumor tissiue by the application of hydrogen peroxide, thus re-oxygenizing the tumor tissue by the oxygen produced by the hydrogen peroxide degradation. In this way, we can convert radioresistant tumors into radiosensitive ones.On the basis of this strategy, we have developed a new enzyme-targeted radiosensitization treatment named KORTUC I (Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type I), which remarkably enhances the radiotherapeutic effect on various types of superficial & locally advanced malignant neoplasms. In the method, the surface of the tumor is covered by hydrogen peroxide solution (Oxydol)-soaked gauze during each administration of radiation therapy.Based on our clinical experiences using KORTUC I, we also developed a new radiosensitizer containing hydrogen peroxide and sodium hyaluronate for topical tumor injection for various types of tumors which are not superficially exposed (KORTUC II). KORTUC II was accepted by our local ethical committee concerning of the use for skin cancer, bone/soft tissue malignant neoplasms, breast cancer, and metastatic lymph nodes. Maximally 3 ml of the agent was injected into topical tumor tissue, one to two times per week, under an ultrasonographic guide just prior to each administration of radiation therapy.Fifteen patients including 10 breast cancer patients were enrolled in the KORTUC II trial upon fully informed consent. Twelve of the patients showed clinically complete response by the new enzyme-targeting radiosensitization treatment (KORTUC II) without any severe complications. The method can be indicated for various types of locally advanced neoplasms.

使用当前使用的线性加速器，我们打算通过施用过氧化氢在局部肿瘤组织中灭活过氧化物酶/过氧化酶，从而通过过氧化氢降解产生的氧气将肿瘤组织重新氧化。通过这种方式，我们可以将辐射耐药性肿瘤转化为放射敏感性的肿瘤。在该策略的基础上，我们开发了一种新的酶靶向的放射性放射密度治疗，称为Kortuc I（高知甲醇放射疗法（高知甲氧醇辐射疗法），用于不可切除的癌症，I型），从而极大地增强了对放射性疗效的较高效果，以较为层次的不友好效应。在该方法中，肿瘤的表面被过氧化氢溶液（Oxydol）覆盖在辐射治疗期间。在我们使用Kortuc I的临床经验上，我们还开发了一种含有过氧化氢和透明质酸氢化氢的新型放射性辐射剂，用于透明体肿瘤的局部肿瘤注射，以替代各种类型的tumorcuctic II（expectection of Tumuccuccuccuccuccuccuccuccucemines in-kortficcuccuccuccemines intelficcucticals在kortficcucticals上）。 Kortuc II被我们当地的道德委员会接受，涉及对皮肤癌，骨/软组织恶性肿瘤，乳腺癌和转移性淋巴结的使用。在每次放射治疗之前，根据超声指南，将最大3 mL的药物注入局部肿瘤组织，每周一到两次。13例患者，包括10例乳腺癌患者，一旦获得全面知情同意，就将参加Kortuc II试验。十二名患者通过新的靶向酶的放射敏治疗（KORTUC II）表现出临床完全的反应，而没有任何严重的并发症。该方法可以针对各种类型的局部高级肿瘤指示。

项目成果

Preoperative assessment of vascular anatomy of inferior mesenteric artery by volume-rendered 3D-CT for laparoscopic lymph node…..

腹腔镜淋巴结容积渲染 3D-CT 术前评估肠系膜下动脉血管解剖结构......

• 发表时间: 2006
• 期刊: World J Gastroenterol 12
• 作者: Kobayashi M;Morishita S;Okabayashi T;Miyatake K;et al.
• 通讯作者: et al.

Development and clinical application of a new radiosensitizer containing hydrogen peroxide and sodium hyaluronate for topical tumor injection

新型过氧化氢透明质酸钠肿瘤局部注射放射增敏剂的研制及临床应用

• 期刊: International Journal of Radiation Oncology, Biology & Physics

Emergency pancreatoduodenectomy for pancreatic metastasis from renal cell carcinoma in a patient with von Hipple-Lindau disease :

冯·希普尔-林道病患者肾细胞癌胰腺转移的紧急胰十二指肠切除术：

• 发表时间: 2006
• 期刊: Digestive Disease Science (Published online)
• 作者: Maeda H;Okabayashi T;Kobayashi M;Araki K;Kohsaki T;et al.
• 通讯作者: et al.

New radiosensitization treatment(KORTUC I) using hydrogen peroxide solution-soaked gauze bolus for unresectable and superficially exposed neoplasms

使用过氧化氢溶液浸泡的纱布丸进行新型放射增敏治疗（KORTUC I）治疗不可切除和表面暴露的肿瘤

• 发表时间: 2008
• 期刊: Oncology Reports
• 影响因子: 4.2

New enzyme-targeting radiosensitization treatment using a newly-developed radiosensitizer containing hydrogen peroxide & sodium hyaluronate for topical tumor injection

使用新开发的含有过氧化氢的放射增敏剂的新型酶靶向放射增敏治疗

• 发表时间: 2007
• 作者: 小川 恭弘;ほか
• 通讯作者: ほか