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Identification of the therapeutic effect of new enzyme-targeting radiosensitization treatment, KORTUC for tumor stem cells

Identification of the therapeutic effect of new enzyme-targeting radiosensitization treatment, KORTUC for tumor stem cells
新型酶靶向放射增敏治疗KORTUC对肿瘤干细胞的治疗效果鉴定
批准号:
21591610
负责人:
OGAWA Yasuhiro
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Using PET-CT and MRI, the therapeutic effects of new enzyme-targeting radiosensitization treatment, KORTUC were evaluated following the treatment for breast cancer patients treated by KORTUC without any surgical procedure. CD44-positive breast cancer cells thought to be breast cancer stem cells were detected by an immunohistochemical method using biopsy specimens obtained prior to the treatment. As a results, it was concluded that KORTUC exerted fully therapeutic effect irrespective of the existence of CD44-positive tumor cells.
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DOI: 10.3892/etm.2010.123
发表时间: 2010-09-01
期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE
影响因子: 2.7
作者: [Hitomi, Jiro, Kubota, Kei, Nishioka, Akihito]
通讯作者: Nishioka, Akihito
Safety and efficacy of new enzyme targeting intraoperative radiotherapy for locally advanced pancreatic cancer
新型酶靶向术中放疗治疗局部晚期胰腺癌的安全性和有效性
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Nishioka A, Ogawa Y, Kariya S, Miyatake K, Tadokoro M, Ue H, Matsui R, Hamada N, Kubota K]
通讯作者: Kubota K
Phase I study of intra-tumoral injection of a newly developed enzyme-targeting radiosensitizer(KORTUC)containing hydrogen peroxide…
新开发的含过氧化氢的酶靶向放射增敏剂(KORTUC)瘤内注射的 I 期研究......
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Toita T, Kato S, Ishikura S, et al, 小川恭弘]
通讯作者: 小川恭弘
癌の臨床特集酵素標的・増感放射線療法KORTUCの基礎と臨床
癌症临床专题:KORTUC、酶靶向和增敏放射治疗的基础和临床实践
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [小川恭弘, 他]
通讯作者:
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