Identification of the therapeutic effect of new enzyme-targeting radiosensitization treatment, KORTUC for tumor stem cells

新型酶靶向放射增敏治疗KORTUC对肿瘤干细胞的治疗效果鉴定

• 批准号: 21591610
• 负责人: OGAWA Yasuhiro
• 金额: $ 3.08万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591610/
• 关键词: 放射線腫瘍学; 乳癌; 過酸化水素; 腫瘍幹細胞; ヒアルロン酸; 放射線増感剤; KORTUC; オキシドール; CD44; 放射線治療; 低酸素細胞; 酸素化; リソソーム; アポトーシス; 酵素化

Using PET-CT and MRI, the therapeutic effects of new enzyme-targeting radiosensitization treatment, KORTUC were evaluated following the treatment for breast cancer patients treated by KORTUC without any surgical procedure. CD44-positive breast cancer cells thought to be breast cancer stem cells were detected by an immunohistochemical method using biopsy specimens obtained prior to the treatment. As a results, it was concluded that KORTUC exerted fully therapeutic effect irrespective of the existence of CD44-positive tumor cells.

使用PET-CT和MRI，评价新酶靶向放射增敏治疗KORTUC对未经任何手术治疗的乳腺癌患者的治疗效果。使用治疗前获得的活检标本，通过免疫组织化学方法检测被认为是乳腺癌干细胞的CD 44阳性乳腺癌细胞。因此，可以得出结论，KORTUC发挥了充分的治疗效果，无论是否存在CD 44阳性肿瘤细胞。

项目成果

Non-surgical therapy and radiologic assessment of stage I breast cancer treatment with novel enzyme-targeting radiosensitization: Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, type II (KORTUC II)

• DOI: 10.3892/etm.2010.123
• 发表时间: 2010-09-01
• 期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE
• 影响因子: 2.7
• 作者: Hitomi, Jiro;Kubota, Kei;Nishioka, Akihito
• 通讯作者: Nishioka, Akihito

Safety and efficacy of new enzyme targeting intraoperative radiotherapy for locally advanced pancreatic cancer

新型酶靶向术中放疗治疗局部晚期胰腺癌的安全性和有效性

• 发表时间: 2010
• 作者: Nishioka A;Ogawa Y;Kariya S;Miyatake K;Tadokoro M;Ue H;Matsui R;Hamada N;Kubota K
• 通讯作者: Kubota K

Phase I study of intra-tumoral injection of a newly developed enzyme-targeting radiosensitizer(KORTUC)containing hydrogen peroxide…

新开发的含过氧化氢的酶靶向放射增敏剂（KORTUC）瘤内注射的 I 期研究......

• 发表时间: 2009
• 作者: Toita T;Kato S;Ishikura S;et al;小川恭弘
• 通讯作者: 小川恭弘

癌の臨床特集酵素標的・増感放射線療法KORTUCの基礎と臨床

癌症临床专题：KORTUC、酶靶向和增敏放射治疗的基础和临床实践

• 发表时间: 2011
• 作者: 小川恭弘;他
• 通讯作者: 他

COMBINATION TREATMENT OF HYDROGEN PEROXIDE AND X-RAYS INDUCES APOPTOSIS IN HUMAN PROSTATE CANCER PC-3 CELLS

• DOI: 10.1016/j.ijrobp.2009.04.092
• 发表时间: 2009-10-01
• 期刊: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
• 影响因子: 7
• 作者: Kariya, Shinji;Sawada, Ken;Ogawa, Yasuhiro
• 通讯作者: Ogawa, Yasuhiro