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Systematic analysis of the neural circuits in the higher visual centers of the Drosophila brain

果蝇大脑高级视觉中心神经回路的系统分析

基本信息

批准号：
18370060
负责人：
ITO Kei
金额：
$ 10.92万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18370060/
关键词：
Drosophila visual system higher visual center glomeruli projection neuron centrifugal pathway centripetal pathway GAL4 enhancer trap 前部視覚中枢情報の統合嗅覚系聴覚系

项目摘要

In spite of its importance in the visual information processing, relatively little is known about the visual projection neurons that connect the lower visual centers in the optic lobe and higher visual centers in the central brain of insects. By analyzing the neuropil structures of the putative higher visual centers of Drosophila melanogaster and sysmatically identifying and classifying the morphology of the visual projection neurons from the screening of about 4,000 GAL4 enhancer-trap strains, we analyzed how neural pathways that are associated with the lobula and lobula plate of the optic lobe terminate in the central brain. We also analyzed the direction of information in each identified neurons by selectively visualizing the distribution of the presynaptic (output) sites. Among the 24 pathways we identified, all the columnar pathways were centripetal, whereas 70% of the tangential/tree-like pathways were centrifugal. Centripetal VPNs convey visual information to three higher visual centers: the optic tubercle, ventrolateral protocerebrum, and posteriorlateral protocerebrum. On the other hand, most centrifugal VPNs arise from other areas of the brain, suggesting that the signals that regulate the optic lobe activity are not generated by simple feedback loops.

尽管视觉投射神经元在视觉信息处理中具有重要作用，但对昆虫视叶中连接低级视觉中枢和中枢脑中高级视觉中枢的视觉投射神经元的研究却相对较少。通过对果蝇（Drosophilamelanogaster）高级视觉中枢神经元结构的分析，以及对4,000个GAL 4增强子-陷阱（enhancer-trap）菌株的视觉投射神经元形态学的系统识别和分类，我们分析了与视叶小叶和小叶板相关的神经通路在中枢的终止方式。我们还通过选择性地可视化突触前（输出）部位的分布来分析每个识别出的神经元中的信息方向。在我们确定的24条通路中，所有的柱状通路都是向心的，而70%的切向/树状通路是离心的。向心VPN将视觉信息传递到三个更高的视觉中心：视结节，腹外侧前脑和后外侧前脑。另一方面，大多数离心VPN来自大脑的其他区域，这表明调节视叶活动的信号不是由简单的反馈回路产生的。