Analysis of non-olfactory sensory pathways that are necessary for the olfactory associative learning of the Drosophila mushroom body

果蝇蘑菇体嗅觉联想学习所需的非嗅觉感觉通路分析

• 批准号: 21300117
• 负责人: ITO Kei
• 金额: $ 12.23万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300117/
• 关键词: ショウジョウバエ; 嗅覚系; 味覚系; 投射神経; 情報の統合; 学習記憶; GAL4エンハンサートラップ; LexAエンハンサートラップ

The mushroom body is known to be an important center for associative olfactory memory in the insect brain. To understand the neural pathways of information other than the olfactory signals toward this center, we first analyzed the organization of the primary gustatory center, whose structure was hardly known despite the importance of gustatory information in associative olfactory learning. We also analyzed the neural connections of the brain regions that receive the arborizations of the input/output neurons of the mushroom body. By systematically labeling neurons according to cell lineage, we found that no neurons from the gustatory, auditory and visual centers directly project to these regions and that there are distinct regions that receive the projections from putative higher-associative centers.

蘑菇体是昆虫大脑中重要的嗅觉记忆中心。为了了解信息的神经通路以外的嗅觉信号到这个中心，我们首先分析了组织的初级味觉中心，其结构几乎是未知的，尽管味觉信息的重要性，在联想嗅觉学习。我们还分析了接受蘑菇体输入/输出神经元分支的大脑区域的神经连接。通过系统地标记神经元根据细胞谱系，我们发现，没有神经元从味觉，听觉和视觉中心直接投射到这些地区，有不同的地区，接受来自假定的高级联想中心的投影。

项目成果

Comprehensive analysis of the neural network in Drosophila brain on the neuroblast lineages

果蝇大脑神经网络对神经母细胞谱系的综合分析

• 发表时间: 2010
• 作者: 伊藤正芳;遠藤啓太;伊藤啓
• 通讯作者: 伊藤啓

Flybrain Neuron Database: A Comprehensive Database System of the Drosophila Brain Neurons

• DOI: 10.1002/cne.22540
• 发表时间: 2011-04-01
• 期刊: JOURNAL OF COMPARATIVE NEUROLOGY
• 影响因子: 2.5
• 作者: Shinomiya, Kazunori;Matsuda, Keiji;Ito, Kei
• 通讯作者: Ito, Kei

Olfactory Receptor Neuron Identity is Diversified by the Drosophila Evi1/Prdm16 Homologue Hamlet that Mediates Chromatin Modification at Notch-Target Loci

果蝇 Evi1/Prdm16 同源哈姆雷特介导 Notch 靶位点染色质修饰，使嗅觉受体神经元身份多样化

• 发表时间: 2011
• 作者: 遠藤啓太;MD Rezaul Karim;Alena Krejci;Emi Kinameri;Hiroaki Taniguchi;Matthias Siebert,伊藤啓;Sarah J. Bray;Adrian W. Moore
• 通讯作者: Adrian W. Moore

Olfactory Receptor Neurons are Diversified by the Prdm Protein Hamlet that Mediates Chromatin Modification at Notch-Target Loci

Prdm 蛋白 Hamlet 介导 Notch 目标位点染色质修饰，从而使嗅觉受体神经元多样化

• 发表时间: 2011
• 作者: 遠藤啓太;MD Rezaul Karim;Alena Krejci;Emi Kinameri;Hiroaki Taniguchi;Matthias Siebert,伊藤啓;Sarah J. Bray;Adrian W. Moore
• 通讯作者: Adrian W. Moore

Projectome Mapping of the Lineage-Dependent Neural Circuits in the Drosophila Brain

果蝇大脑中谱系依赖性神经回路的投影组图谱

• 发表时间: 2011
• 作者: 伊藤正芳,遠藤啓太,伊藤啓