A STUDY ON EFFECTIVE GC-MS PERFORMANCE FOR ANALYSIS OF MULTI DRUG EXAMINATION IN BODY MATERIALS
A STUDY ON EFFECTIVE GC-MS PERFORMANCE FOR ANALYSIS OF MULTI DRUG EXAMINATION IN BODY MATERIALS
批准号:
18390207
负责人:
HARA Kenji
金额:
$10.27万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2008
中文摘要
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英文摘要
剖検試料から薬毒物を広く分析することで、死体の生前の健康状況を診断する情報を得ることができる。しかし、薬毒物は多種多様であり、剖検で薬物情報を得るには多種類の分析が必要で、時間がかかる。そこで、本研究では、ガスクロマトグラフィー質量分析法(GC-MS)の測定を高速化し、時間短縮を検討した。2種類の短い分析カラムを連結することで、従来30分程度かかっていた1グループの薬物の測定を5分ぐらいに短縮できた。さらに、覚せい剤の光学異性体分離分析についても高速化の条件を設定できた。本研究で開発した技術は、法医中毒学分野の他、GC-MS分析を必要とする分野にも応用可能である。
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Rapid chiral analysis of urinary amphetamines by gas chromatography/mass spectrometry using single-step extraction with TPC-chiral derivatization.
使用单步萃取和 TPC 手性衍生化,通过气相色谱/质谱法对尿安非他明进行快速手性分析。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Fujii H, Hara K, Kashimura S他4名, 藤井広志]
通讯作者:
藤井広志
Rapid GC-MS analysis of methamphetamine and its metabolites in urine-application of a short narrow-bore capillary column to GC-MS
尿液中甲基苯丙胺及其代谢物的快速 GC-MS 分析——窄孔短毛细管柱在 GC-MS 中的应用
DOI:
--
发表时间:
2006
期刊:
Journal of Chromatography B 8421
影响因子:
--
作者:
[Fujii H, Hara K, Kashimura S他4名]
通讯作者:
Kashimura S他4名
High throughput chiral analysis of urinary amphetamines by GC-MS using a short narrow-bore capillary column
使用短窄孔毛细管柱通过 GC-MS 对尿安非他明进行高通量手性分析
DOI:
--
发表时间:
2009
期刊:
Forensic Toxicology, DOI 10.1007/s11419-009-0073-2 (in press)
影响因子:
--
作者:
[Hiroshi Fujii, Kenji Hara, Mitsuyoshi Kageura, Masayuki Kashiwagi, Aya Matsusue, Shin-ichi Kubo]
通讯作者:
Shin-ichi Kubo
Rapid GC-MS analysis of methamphetamine and its metabolites in urine - application of a short narrow-bore capillary column to GC-MS
尿液中甲基苯丙胺及其代谢物的快速 GC-MS 分析 - 短窄孔毛细管柱在 GC-MS 中的应用
DOI:
--
发表时间:
2006
期刊:
Journal of Chromatography B 842
影响因子:
--
作者:
[Hiroshi Fujii, Kenji Hara, Seiichi Kashimura, Mitsuyoshi Kageura, Masayuki Kashiwagi, Aya Miyoshi, Sachiko Ikeda]
通讯作者:
Sachiko Ikeda
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