Development of new therapy for vitreoretinal disorders with enzymatic vitreolysis

酶促玻璃体溶解术治疗玻璃体视网膜疾病的新疗法的开发

• 批准号: 18599005
• 负责人: HIRATA Akira
• 金额: $ 2.43万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18599005/
• 关键词: plasmin; vitrectomv; 網膜; 硝子体; プラスミン

Establishment of vitreous surgery with plasmin: After institutional review board approval, vitrectomy with using plasmin was performed for 6 eyes of 4 patients. All eyes treated with autologous plasmin required significantly less surgical time. Also, we published our data regarding beneficial results in the surgical management of proliferative diabetic retinopathy and retinopathy of prematurity usefulness. All eyes showed visualEffect of bevacizumab on choriocapillaris : We presented that bevacizumab injected into the vitreous cavity caused decrease of the number of fenestrae in choriocapillarisEffect of retinal sealant with enzymatic vitreolysis : We are still investigating the effect of retinal sealant with enzymatic vitreolysis on experimental retinal detachment in rabbit eye.

玻璃体手术应用纤溶酶的建立：经机构审查委员会批准，对4例患者6眼进行玻璃体手术应用纤溶酶。用自体纤溶酶治疗的所有眼睛所需的手术时间均显著缩短。此外，我们发表了关于增生性糖尿病视网膜病变和早产儿视网膜病变手术治疗的有益结果的数据。贝伐单抗对脉络膜毛细血管的影响：我们报道贝伐单抗注入玻璃体腔导致脉络膜毛细血管内孔数减少；酶溶玻璃体视网膜封闭剂的作用：我们仍在研究酶溶玻璃体视网膜封闭剂对兔眼实验性视网膜脱离的影响。

项目成果

プラスミン注入後の空気タンポナーデによる実験的後部硝子体剥離作製

纤溶酶注射后空气填塞造成实验性玻璃体后脱离

• 发表时间: 2007
• 期刊: 眼科臨床医報
• 作者: 下村 由起子;平田 憲;沖波 聡
• 通讯作者: 沖波 聡

Plasmin-assisted vitrectomy for management of proliferative membrane in proliferative diabetic retinopathy.

纤溶酶辅助玻璃体切除术用于治疗增殖性糖尿病视网膜病变中的增殖膜。

• 发表时间: 2007
• 期刊: Retina 27
• 作者: Hirata;A.;Talcano;A.;Inomata;Y.;Yonemura;N.;Sagara;N.;Tanihara;H
• 通讯作者: H

Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia

• DOI: 10.1007/s00417-007-0666-6
• 发表时间: 2008-01-01
• 期刊: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
• 影响因子: 2.7
• 作者: Hirata, Akira;Inatani, Masaru;Tanihara, Hidenobu
• 通讯作者: Tanihara, Hidenobu

Plasmin-assisted vitrectomy for management of proliferative membrane in prolifbrative diabetic retinopathy

纤溶酶辅助玻璃体切除术治疗增殖性糖尿病视网膜病变的增殖膜

• 发表时间: 2007
• 期刊: Retina 27
• 作者: Hirata A;Takano A;Inomata Y;Yonemura N;Sagara N;Tanihara H.
• 通讯作者: Tanihara H.

Autologous Plasmin Assisted Vitrectomy for Stage 5 Retinopathy of Prematurity

自体纤溶酶辅助玻璃体切除术治疗 5 期早产儿视网膜病变

• 发表时间: 2007
• 期刊: Am J Ophthalmol 143(In press)
• 作者: Tsukahara Y;et al.
• 通讯作者: et al.