Feasibility of using bio adhesives to repair retinal detachment and ischemic retinal diseases.

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Although surgical strategies for rhegmatogenous retinal detachment treatments developed, there is still room for improvement. In this project, we investigated the effect of using gelatin-microbial transglutaminase (gelatin-mTG) complex for treating experimental retinal detachment. Gelatin-mTG complex covered the retinal tear for more than 7 days after the vitrectomy with less prominent inflammation. Reattachment of the retina occurred in all treated eyes. In addition, we investigated the temporary tamponade effects of an ophthalmic viscosurgical device (OVD) for experimental retinal detachment. The OVD on the retinal surface had disappeared and the retina was reattached. Furthermore, the usefulness of rigid endoscopy placed on the corneal surface to observe the peripheral retina was evaluated. This technique was simple to manipulate and useful for observing the peripheral retina, in particular, in aphakic and pseudo-phakic eyes.