Feasibility of using bio adhesives to repair retinal detachment and ischemic retinal diseases.

尽管孔源性视网膜脱离的手术治疗策略已经开发出来，但仍有改进的空间。本课题研究了明胶-微生物转谷氨酰胺酶复合体(明胶-MTG)对实验性视网膜脱离的治疗作用。玻璃体切除术后明胶-MTG复合体覆盖视网膜裂孔7天以上，炎症较轻。所有接受治疗的眼均发生视网膜再附着。此外，我们还研究了眼科粘性手术装置(OVD)对实验性视网膜脱离的临时填塞效果。视网膜表面的OVD消失，视网膜重新附着。此外，对放置在角膜表面的刚性内窥镜观察周边视网膜的有效性进行了评估。这项技术操作简单，对观察周边视网膜很有用，特别是在无晶状体眼和人工有晶状体眼。

Although surgical strategies for rhegmatogenous retinal detachment treatments developed, there is still room for improvement. In this project, we investigated the effect of using gelatin-microbial transglutaminase (gelatin-mTG) complex for treating experimental retinal detachment. Gelatin-mTG complex covered the retinal tear for more than 7 days after the vitrectomy with less prominent inflammation. Reattachment of the retina occurred in all treated eyes. In addition, we investigated the temporary tamponade effects of an ophthalmic viscosurgical device (OVD) for experimental retinal detachment. The OVD on the retinal surface had disappeared and the retina was reattached. Furthermore, the usefulness of rigid endoscopy placed on the corneal surface to observe the peripheral retina was evaluated. This technique was simple to manipulate and useful for observing the peripheral retina, in particular, in aphakic and pseudo-phakic eyes.