Feasibility of using bio adhesives to repair retinal detachment and ischemic retinal diseases.

使用生物粘合剂修复视网膜脱离和缺血性视网膜疾病的可行性。

• 批准号: 23592576
• 负责人: HIRATA Akira
• 金额: $ 3.33万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592576/
• 关键词: 網膜剥離; トランスグルタミナーゼ; 眼科用粘弾性物質; 硬性内視鏡; 網膜糊; 網膜静脈閉塞; ｍTG; OVD; 硝子体手術; 網膜接着糊

Although surgical strategies for rhegmatogenous retinal detachment treatments developed, there is still room for improvement. In this project, we investigated the effect of using gelatin-microbial transglutaminase (gelatin-mTG) complex for treating experimental retinal detachment. Gelatin-mTG complex covered the retinal tear for more than 7 days after the vitrectomy with less prominent inflammation. Reattachment of the retina occurred in all treated eyes. In addition, we investigated the temporary tamponade effects of an ophthalmic viscosurgical device (OVD) for experimental retinal detachment. The OVD on the retinal surface had disappeared and the retina was reattached. Furthermore, the usefulness of rigid endoscopy placed on the corneal surface to observe the peripheral retina was evaluated. This technique was simple to manipulate and useful for observing the peripheral retina, in particular, in aphakic and pseudo-phakic eyes.

尽管孔源性视网膜脱离的手术治疗策略已经开发出来，但仍有改进的空间。本课题研究了明胶-微生物转谷氨酰胺酶复合体(明胶-MTG)对实验性视网膜脱离的治疗作用。玻璃体切除术后明胶-MTG复合体覆盖视网膜裂孔7天以上，炎症较轻。所有接受治疗的眼均发生视网膜再附着。此外，我们还研究了眼科粘性手术装置(OVD)对实验性视网膜脱离的临时填塞效果。视网膜表面的OVD消失，视网膜重新附着。此外，对放置在角膜表面的刚性内窥镜观察周边视网膜的有效性进行了评估。这项技术操作简单，对观察周边视网膜很有用，特别是在无晶状体眼和人工有晶状体眼。

项目成果

Occurrence of capsular delamination in the dislocated in-the-bag intraocular lens.

袋内人工晶状体脱位后发生囊膜分层。

• 发表时间: 2011
• 期刊: Graefes Arch Clin Exp Ophthalmol.
• 作者: Hirata A;Okinami S;Hayashi K.
• 通讯作者: Hayashi K.

A simulated eye for vitreous surgery using Japanese quail eggs

• DOI: 10.1007/s00417-012-2247-6
• 发表时间: 2013-06-01
• 期刊: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
• 影响因子: 2.7
• 作者: Hirata, Akira;Iwakiri, Ryo;Okinami, Satoshi
• 通讯作者: Okinami, Satoshi

Eccrine Hidrocystoma Arising at the Tarsal Plate during Childhood

儿童期发生于跗骨板的小汗腺汗囊瘤

• 发表时间: 2013
• 期刊: Case Rep Ophthalmol
• 影响因子: 0.4
• 作者: Yoshida;S. Ishikawa;K. Asato;R. Sassa;Y. Yoshikawa;H. Izuhara;K. Kono;T. Ishibashi;T.;Hirata A
• 通讯作者: Hirata A

Observation of peripheral retina by topical endoscopic imaging method-a preliminary study.

• DOI: 10.1007/s40123-012-0008-6
• 发表时间: 2013-06
• 期刊: OPHTHALMOLOGY AND THERAPY
• 影响因子: 3.3
• 作者: Hirata, Akira;Ishikawa, Shinichiro;Okinami, Satoshi
• 通讯作者: Okinami, Satoshi

Viability of topical endoscopic imaging system for vitreous surgery in rabbit eyes

兔眼玻璃体手术局部内窥镜成像系统的可行性

• 发表时间: 2012
• 期刊: Ophthalmic Surg Lasers Imaging
• 作者: Hirata A;Okinami S
• 通讯作者: Okinami S