Study for reciprocal double effects of nociceptin on spinal pain transmission.
Study for reciprocal double effects of nociceptin on spinal pain transmission.
批准号:
18613015
负责人:
WATANABE Chizuko
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2009
中文摘要
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英文摘要
The involvement of various neurotransmitters on spinal pain transmission was investigated in this project. As the results, it was found that nociceptin, hemokinin, histamine, endogenous cannabinoid, endogenous polyamine, as well as substance P and glutamate, participated on spinal pain transmission, and the spinal pain transmission was regulated by the mutual control of these neurotransmitter-containing neurons. In addition, it was also found that the supersensitivity of these neurotransmitters was occurred at the stage of the neuropathic pain to increase the pain sensation.
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Spermidine誘発性疼痛関連行動の発現機序に関する行動薬理学的検討
亚精胺诱发疼痛相关行为机制的行为药理学研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yoshimura M., et. al., 瀧澤裕]
通讯作者:
瀧澤裕
Possible involvement of endogenous nociceptin/orphanin FQ in the pain- related behavioral responses induced by its own metabolite
内源性伤害感受肽/孤啡肽 FQ 可能参与其自身代谢物诱导的疼痛相关行为反应
DOI:
--
发表时间:
2007
期刊:
nociceptin/orphanin FQ(14-17) 28
影响因子:
--
作者:
[Hiroyuki Watanabe, Hirokazu Mizoguchi, Tohru Orito, Sou Katsuyama, Akihiko Yonezawa, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada]
通讯作者:
Shinobu Sakurada
CB2受容体拮抗薬の脊髄くも膜下腔内投与による疼痛関連行動の発現について
鞘内注射CB2受体拮抗剂对疼痛相关行为的影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[加藤慧, 長岡高史]
通讯作者:
長岡高史
Intrathecal high-dose histamine induces spinally-mediated behavioral response through a polyamine site of NMDA receptors
鞘内注射高剂量组胺通过 NMDA 受体的多胺位点诱导脊髓介导的行为反应
DOI:
--
发表时间:
2008
期刊:
Eur. J. Pharmacol. 581
影响因子:
--
作者:
[Chizuko Watanabe, Tohru Orito, Hiroyuki Watanabe, Hirokazu Mizoguchi, Akihiko Yonezawa, Kazuhiko Yanai, Jalal I. Mobarakeh, Kenji Onodera, Tsukasa Sakurada, Shinobu Sakurada]
通讯作者:
Shinobu Sakurada
Possible involvement of endogenous nociceptin/orphanin FQ in the painrelated behavioral responses induced by its own metabolite, nociceptin/ orphaninFQ(14-17)
内源性伤害感受肽/孤啡肽 FQ 可能参与其自身代谢物伤害感受肽/孤啡肽 FQ 诱导的疼痛相关行为反应 (14-17)
DOI:
--
发表时间:
2007
期刊:
Peptides 28
影响因子:
--
作者:
[Hiroyuki Watanabe, Hirokazu Mizoguchi, Tohru Orito, Sou Katsuyama, Akihiko Yonezawa, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada]
通讯作者:
Shinobu Sakurada
共 13 条
Investigation for the mechanism of neuropathic pain on spinal pain transmission.
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批准号:23590718
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2011
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负责人:WATANABE Chizuko
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依托单位:
海外基金