Advanced Control of Catalytic Activity and Stereoselectivity in Catalytic Asymmetric Reactions

开发同时具有高催化活性和高对映体选择性的新型手性配体是不对称催化研究的重要课题之一。我们已经成功地开发了一种全新的手性配体，它具有与金属催化剂配位的烯烃功能。其中，手性二烯配体在Rh和Ir催化的不对称碳-碳键形成反应中表现出良好的催化活性和对映体选择性。

One of the most important subjects in studying asymmetric catalysis is development of new chiral ligands which have both high catalytic activity and high enantioselectivity. We have successfully developed an entirely new type of chiral ligands which have olefins as coordinating functionalities to metal catalysts. Among them, chiral diene ligands showed great performance in terms of both catalytic activity and enantioselectivity in rhodium- and iridium-catalyzed asymmetric carbon-carbon bond forming reactions.