Advanced Control of Catalytic Activity and Stereoselectivity in Catalytic Asymmetric Reactions

催化不对称反应中催化活性和立体选择性的高级控制

• 批准号: 19105002
• 负责人: HAYASHI Tamio
• 金额: $ 70.8万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19105002/
• 关键词: 触媒的不斉合成; 遷移金属錯体触媒; 不斉配位子; キラルジエン配位子; 触媒活性; 不斉付加反応; 不斉重合; ロジウム触媒; イリジウム触媒; 銅触媒; 反応機構

One of the most important subjects in studying asymmetric catalysis is development of new chiral ligands which have both high catalytic activity and high enantioselectivity. We have successfully developed an entirely new type of chiral ligands which have olefins as coordinating functionalities to metal catalysts. Among them, chiral diene ligands showed great performance in terms of both catalytic activity and enantioselectivity in rhodium- and iridium-catalyzed asymmetric carbon-carbon bond forming reactions.

开发具有高催化活性和高对映选择性的新型手性配体是不对称催化研究的重要课题之一。我们已经成功地开发了一种全新类型的手性配体，其具有烯烃作为金属催化剂的配位功能。其中，手性二烯配体在铑和铱催化的不对称碳-碳键形成反应中表现出优异的催化活性和对映选择性。

项目成果

Asymmetric 1,4‐Addition of Organoboron Reagents to Quinone Monoketals Catalyzed by a Chiral Diene/Rhodium Complex: A New Synthetic Route to Enantioenriched 2‐Aryltetralones

• DOI: 10.1002/adsc.200600632
• 发表时间: 2007-03
• 期刊: Advanced Synthesis & Catalysis
• 影响因子: 5.4
• 作者: N. Tokunaga;Tamio Hayashi

Organocatalytic asymmetric Mannich-type reaction of N-sulfonylimines with isocyanoacetate leading to optically active 2-imidazoline-4-carboxylates

• DOI: 10.1016/j.tetasy.2010.04.029
• 发表时间: 2010-07
• 期刊: Tetrahedron-asymmetry
• 作者: Zhen-Wei Zhang;G. Lu;Miao-Miao Chen-Miao;Ning Lin;Yong‐Bo Li;Tamio Hayashi;A. Chan

A cationic rhodium-chiral diene complex as a high-performance catalyst for the intramolecular asymmetric [4+2] cycloaddition of alkyne-1,3-dienes.

• DOI: 10.1002/anie.200702586
• 发表时间: 2007-09
• 期刊: Angewandte Chemie
• 作者: R. Shintani;Y. Sannohe;T. Tsuji;Tamio Hayashi

Rhodium-catalyzed oxidative alkynylation of acrylate esters with propargylic alcohols

• DOI: 10.1016/j.tetlet.2010.11.120
• 发表时间: 2011-04
• 期刊: Tetrahedron Letters
• 影响因子: 1.8
• 作者: T. Nishimura;M. Nagaosa;Tamio Hayashi

ロジウム触媒によるN-トシルケトイミンの不斉アリール化反応

铑催化的 N-甲苯磺酰酮亚胺的不对称芳基化

• 发表时间: 2011
• 作者: 劒隼人、真島和志;他3名;竹田桃太郎
• 通讯作者: 竹田桃太郎