Regulatory mechanism of breakdown and reconstruction of reproductive organs

增殖、分化和凋亡（程序性细胞死亡）受细胞分泌的信号分子、激素、生长因子和细胞因子以及细胞周围的细胞外基质调节。本研究旨在探讨小鼠垂体和子宫细胞增殖与凋亡的调控机制。我们显示了与垂体和子宫增殖相关的生长因子和激素的基因表达的调节机制，以及改变生长因子和激素的作用的因素。

Proliferation, differentiation and apoptosis (programmed cell-death) are regulated by signaling molecules secreted from cells, hormones, growth factors and cytokines, and by extracellular matrices surrounding cells. The present study was aimed at studying regulatory mechanism of the proliferation and apoptosis in the mouse pituitary and uterus. We showed regulatory mechanisms of gene expression of growth factors and hormones that were associated with proliferation in the pituitary and uterus, and also factors which modified actions of growth factors and hormones.