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Regulatory Mechanism of Brain-Gut Interactions by Brain-Gut Peptides

Regulatory Mechanism of Brain-Gut Interactions by Brain-Gut Peptides
脑肠肽对脑肠相互作用的调节机制
批准号:
19390189
负责人:
FUKUDO Shin
金额:
$9.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
It is important to clarify the precise mechanism of brain-gut interactions and pathogenesis of irritable bowel syndrome (IBS). We focused on the role of corticotropin-releasing hormone (CRH) in these phenomena. Administration of non-peptide CRH antagonist improved visceral hypersensitivity and flare-up of inflammation in the animal model of IBS after the experimental colitis. Administration of peptide CRH antagonist improved electrophysiological properties of the brain in patients with IBS. Further studies on brain-gut peptides in this issue are warranted.
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DOI: 10.1111/j.1365-2982.2009.01427.x
发表时间: 2010-05-01
期刊: NEUROGASTROENTEROLOGY AND MOTILITY
影响因子: 3.5
作者: [Tana, C., Umesaki, Y., Fukudo, S.]
通讯作者: Fukudo, S.
Role of histaminergic neurons in hypnotic modulation of brain processing of visceral perception
组胺能神经元在内脏知觉大脑处理催眠调节中的作用
DOI: --
发表时间: 2007
期刊: Neurogastroenterol Motil 19
影响因子: --
作者: [Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S.]
通讯作者: Fukudo S.
DOI: 10.1186/1751-0759-2-20
发表时间: 2008-11-04
期刊: BIOPSYCHOSOCIAL MEDICINE
影响因子: 2.1
作者: [Hamaguchi, Toyohiro, Fukudo, Shin, Kanazawa, Motoyori, Tomiie, Tadaaki, Shimizu, Kunihiko, Oyama, Mineo, Sakurai, Kohji]
通讯作者: Sakurai, Kohji
DOI: 10.1007/s00535-006-1942-7
发表时间: 2007-01-01
期刊: JOURNAL OF GASTROENTEROLOGY
影响因子: 6.3
作者: [Fukudo, Shin]
通讯作者: Fukudo, Shin
35
    Impact of susceptible genes and stresss on endophenotype of irritable bowel syndrome
    • 批准号:
      24659344
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2012
    • 负责人:
      FUKUDO Shin
    • 依托单位:
    Role of Brain-Gut Peptides in Pathophysiology of Brain-Gut Interactions
    • 批准号:
      22249024
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.03万
    • 财政年份:
      2010
    • 负责人:
      FUKUDO Shin
    • 依托单位:
    Biomarkers and Gene-Environment Interaction in Irritable Bowel Syndrome
    • 批准号:
      21659178
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.11万
    • 财政年份:
      2009
    • 负责人:
      FUKUDO Shin
    • 依托单位:
    Role of Stress-related Peptide CRH in Brain-Gut Interactions
    • 批准号:
      15390218
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.62万
    • 财政年份:
      2003
    • 负责人:
      FUKUDO Shin
    • 依托单位:
    海外基金