Regulatory Mechanism of Brain-Gut Interactions by Brain-Gut Peptides
Regulatory Mechanism of Brain-Gut Interactions by Brain-Gut Peptides
批准号:
19390189
负责人:
FUKUDO Shin
金额:
$9.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
It is important to clarify the precise mechanism of brain-gut interactions and pathogenesis of irritable bowel syndrome (IBS). We focused on the role of corticotropin-releasing hormone (CRH) in these phenomena. Administration of non-peptide CRH antagonist improved visceral hypersensitivity and flare-up of inflammation in the animal model of IBS after the experimental colitis. Administration of peptide CRH antagonist improved electrophysiological properties of the brain in patients with IBS. Further studies on brain-gut peptides in this issue are warranted.
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DOI:
10.1111/j.1365-2982.2009.01427.x
发表时间:
2010-05-01
期刊:
NEUROGASTROENTEROLOGY AND MOTILITY
影响因子:
3.5
作者:
[Tana, C., Umesaki, Y., Fukudo, S.]
通讯作者:
Fukudo, S.
Role of histaminergic neurons in hypnotic modulation of brain processing of visceral perception
组胺能神经元在内脏知觉大脑处理催眠调节中的作用
DOI:
--
发表时间:
2007
期刊:
Neurogastroenterol Motil 19
影响因子:
--
作者:
[Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S.]
通讯作者:
Fukudo S.
DOI:
10.1186/1751-0759-2-20
发表时间:
2008-11-04
期刊:
BIOPSYCHOSOCIAL MEDICINE
影响因子:
2.1
作者:
[Hamaguchi, Toyohiro, Fukudo, Shin, Kanazawa, Motoyori, Tomiie, Tadaaki, Shimizu, Kunihiko, Oyama, Mineo, Sakurai, Kohji]
通讯作者:
Sakurai, Kohji
DOI:
10.1007/s00535-006-1942-7
发表时间:
2007-01-01
期刊:
JOURNAL OF GASTROENTEROLOGY
影响因子:
6.3
作者:
[Fukudo, Shin]
通讯作者:
Fukudo, Shin
DOI:
10.1016/j.pain.2007.01.032
发表时间:
2007-12-05
期刊:
PAIN
影响因子:
7.4
作者:
[Kano, Michiko, Hamaguchi, Toyohiro, Fukudo, Shin]
通讯作者:
Fukudo, Shin
共 35 条
Impact of susceptible genes and stresss on endophenotype of irritable bowel syndrome
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批准号:24659344
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.25万
-
财政年份:2012
-
负责人:FUKUDO Shin
-
依托单位:
Role of Brain-Gut Peptides in Pathophysiology of Brain-Gut Interactions
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批准号:22249024
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.03万
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财政年份:2010
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负责人:FUKUDO Shin
-
依托单位:
Biomarkers and Gene-Environment Interaction in Irritable Bowel Syndrome
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批准号:21659178
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.11万
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财政年份:2009
-
负责人:FUKUDO Shin
-
依托单位:
Role of Stress-related Peptide CRH in Brain-Gut Interactions
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批准号:15390218
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.62万
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财政年份:2003
-
负责人:FUKUDO Shin
-
依托单位:
Role of Histaminergic Neurons in Brain-GUT Interactions
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批准号:11680778
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:1999
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负责人:FUKUDO Shin
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依托单位:
海外基金