Regulatory Mechanism of Brain-Gut Interactions by Brain-Gut Peptides

脑肠肽对脑肠相互作用的调节机制

• 批准号: 19390189
• 负责人: FUKUDO Shin
• 金额: $ 9.15万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390189/
• 关键词: 脳腸相関; 過敏性腸症候群; corticotropin-releasing hormone (CRH); 内臓感覚; 消化管運動; 脳画像; CRH-R1受容体; α-helical CRH; corticotropin-releasing hormone(CRH); CRH; 消化管知覚; CRH-R1

It is important to clarify the precise mechanism of brain-gut interactions and pathogenesis of irritable bowel syndrome (IBS). We focused on the role of corticotropin-releasing hormone (CRH) in these phenomena. Administration of non-peptide CRH antagonist improved visceral hypersensitivity and flare-up of inflammation in the animal model of IBS after the experimental colitis. Administration of peptide CRH antagonist improved electrophysiological properties of the brain in patients with IBS. Further studies on brain-gut peptides in this issue are warranted.

阐明肠易激综合征（IBS）脑-肠相互作用的确切机制及其发病机制具有重要意义。我们集中在促肾上腺皮质激素释放激素（CRH）在这些现象中的作用。在实验性结肠炎后的IBS动物模型中，施用非肽CRH拮抗剂改善内脏高敏感性和炎症的爆发。肽CRH拮抗剂的管理改善IBS患者的脑电生理特性。因此，对脑肠肽的进一步研究是必要的。

项目成果

Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

• DOI: 10.1111/j.1365-2982.2009.01427.x
• 发表时间: 2010-05-01
• 期刊: NEUROGASTROENTEROLOGY AND MOTILITY
• 影响因子: 3.5
• 作者: Tana, C.;Umesaki, Y.;Fukudo, S.
• 通讯作者: Fukudo, S.

Role of histaminergic neurons in hypnotic modulation of brain processing of visceral perception

组胺能神经元在内脏知觉大脑处理催眠调节中的作用

• 发表时间: 2007
• 期刊: Neurogastroenterol Motil 19
• 作者: Watanabe S;Hattori T;Kanazawa M;Kano M;Fukudo S.
• 通讯作者: Fukudo S.

Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome.

• DOI: 10.1186/1751-0759-2-20
• 发表时间: 2008-11-04
• 期刊: BIOPSYCHOSOCIAL MEDICINE
• 影响因子: 2.1
• 作者: Hamaguchi, Toyohiro;Fukudo, Shin;Kanazawa, Motoyori;Tomiie, Tadaaki;Shimizu, Kunihiko;Oyama, Mineo;Sakurai, Kohji
• 通讯作者: Sakurai, Kohji

Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation

• DOI: 10.1007/s00535-006-1942-7
• 发表时间: 2007-01-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Fukudo, Shin

Correlation between alexithymia and hypersensitivity to visceral stimulation in human

• DOI: 10.1016/j.pain.2007.01.032
• 发表时间: 2007-12-05
• 期刊: PAIN
• 影响因子: 7.4
• 作者: Kano, Michiko;Hamaguchi, Toyohiro;Fukudo, Shin
• 通讯作者: Fukudo, Shin