Development of effective immunotherapy by combining methods to restore immunocompetence of cancer patients
Development of effective immunotherapy by combining methods to restore immunocompetence of cancer patients
批准号:
19390355
负责人:
KAWAKAMI Yutaka
金额:
$12.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
本研究では、効果的な免疫療法の開発のために、消化器癌による免疫抑制の分子機構の解明と克服法の開発、および免疫療法の標的となるヒト消化器癌抗原の同定を試みた。その結果、発現と良好な予後との相関がみられ、免疫原性の高い腫瘍抗原が同定され、さらに、大腸癌シグナル異常による免疫抑制機構が明らかになり、in vitroおよび大腸癌マウスモデルで、シグナル阻害による免疫抑制の解除と免疫療法の効果増強の可能性が示された。
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Immunotherapy by intratumoral administration of dendritic cells
通过瘤内施用树突状细胞进行免疫治疗
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Kawakami Y, Fujita T, Kudo C, Udagawa M, Sakurai T, Ueda Y, Yaguchi T, Sumimoto H]
通讯作者:
Sumimoto H
がん免疫療法の現状と展望.
癌症免疫治疗的现状与展望。
DOI:
--
发表时间:
2022
期刊:
影响因子:
--
作者:
[池田和博, 堀江公仁子, 井上聡, 笹田哲朗.]
通讯作者:
笹田哲朗.
Dendritic cell based personalized immunotherapy based on cancer antigen research
基于癌抗原研究的树突状细胞个性化免疫治疗
DOI:
--
发表时间:
2008
期刊:
Frontiers in Bioscience 1;13
影响因子:
--
作者:
[Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Yaguchi T, Hasegawa G, Hayashi E, Ueda Y, Iwata T, Wang Q, Okada S, Tsukamoto N, Matsuzaki Y, Sumimoto H.]
通讯作者:
Sumimoto H.
Application of tumor cryoablation in the development of cancer immunorherapy
肿瘤冷冻消融在癌症免疫治疗发展中的应用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[塚本信夫, 長谷川豪, 永濱康晴, 大波陽子, 河上裕, Kawakami Y]
通讯作者:
Kawakami Y
DOI:
10.1158/1078-0432.ccr-07-1374
发表时间:
2007-11
期刊:
Clinical Cancer Research
影响因子:
11.5
作者:
[Emiko Hayashi;Yuriko Matsuzaki;Go Hasegawa;T. Yaguchi;S. Kurihara;T. Fujita;T. Kageshita;M. Sano;Y. Kawakami]
通讯作者:
Emiko Hayashi;Yuriko Matsuzaki;Go Hasegawa;T. Yaguchi;S. Kurihara;T. Fujita;T. Kageshita;M. Sano;Y. Kawakami
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Investigation of differential immune status among cancer patients and development of personalized cancer therapy by combining immunomodulation
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批准号:26221005
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项目类别:Grant-in-Aid for Scientific Research (S)
-
资助金额:$124.88万
-
财政年份:2014
-
负责人:KAWAKAMI Yutaka
-
依托单位:
Systematic analysis of cellular signaling involved in the melanoma induced immunosuppression
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批准号:25670506
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2013
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负责人:KAWAKAMI Yutaka
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依托单位:
Development of effective immunotherapy by combining interventions on key points in the anti-tumor immune network
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批准号:23240128
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.37万
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财政年份:2011
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负责人:KAWAKAMI Yutaka
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依托单位:
Investigation of roles of miRNA in the immunosuppression and clinical use for patients with melanoma
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批准号:23659554
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:KAWAKAMI Yutaka
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依托单位:
Development of immunotherapy based on the identification of tumor antigens
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批准号:17016070
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$34.69万
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财政年份:2005
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负责人:KAWAKAMI Yutaka
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依托单位:
Development of new diagnostic and immunotherapeutic methods for patients with cancer
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批准号:14104013
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$70.14万
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财政年份:2002
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负责人:KAWAKAMI Yutaka
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依托单位:
Systematic isolation of genes encoding candidate proteins for human melanoma antigens using serial analysis of gene expression (SAGE) and EST database
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批准号:12470180
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2000
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负责人:KAWAKAMI Yutaka
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依托单位:
Development of diagnositic and therapeutic methods using frameshift mutated peptides for colorectal cancers with microsatellite instability
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批准号:12557109
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2000
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负责人:KAWAKAMI Yutaka
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依托单位:
Isolation of human melanoma antigens recognized bt T cells for development of immunotherapy and gene therapy
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批准号:10557083
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.7万
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财政年份:1998
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负责人:KAWAKAMI Yutaka
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依托单位:
Isolation of human tumor antigens recognized by antibodies for development of immunotherapy and gene therapy
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批准号:10470264
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.38万
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财政年份:1998
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负责人:KAWAKAMI Yutaka
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依托单位:
海外基金