Development of immunotherapy based on the identification of tumor antigens
Development of immunotherapy based on the identification of tumor antigens
批准号:
17016070
负责人:
KAWAKAMI Yutaka
金额:
$34.69万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
Cancer immunotherapy has not been established as a standard cancer therapy. To improve current immunotherapy, in this project we have identified new human tumor antigens, revealed cancer immune responses particularly cancer induced immunosuppression, and evaluated immunological characteristics of cancer stem cells and epithelial-mesenchymal transitioned cancer cells. Newly identified tumor antigens and immune modulation methods may lead to development of new diagnostic and therapeutic methods for cancer.
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MITF protein levels determine the proliferation status of melanoma cells
MITF蛋白水平决定黑色素瘤细胞的增殖状态
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Sumimoto H, et. al.]
通讯作者:
et. al.
The proliferation of melanoma cells depends on the protein levels of MITF
黑色素瘤细胞的增殖取决于 MITF 的蛋白水平
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[住本秀敏, 木藤健治, 浅田咲世, 岡田スターリン, 谷口智憲, 斎田俊雄, 河上裕]
通讯作者:
河上裕
Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6.
通过含有神经胶质瘤抗原 SOX6 的 DNA 疫苗诱导保护性和治疗性抗肿瘤免疫。
DOI:
--
发表时间:
2008
期刊:
Int J Cancer. 122
影响因子:
--
作者:
[Ueda R., et al.]
通讯作者:
et al.
Simultaneous suppression of MITF and BRAFV600E enhanced inhibition of melanoma cell proliferation.
同时抑制 MITF 和 BRAFV600E 增强了对黑色素瘤细胞增殖的抑制。
DOI:
--
发表时间:
2009
期刊:
Cancer Sci. 100(10)
影响因子:
--
作者:
[Kido K. Sumimoto H, Asada S, Okada S, Yaguchi T, Kawamura N, Miyagishi M, Saida M, Kawakami Y]
通讯作者:
Kawakami Y
Molecular mechanisms for generation ofo immunosuppressive microenviroment by cancer cells
癌细胞产生ofo免疫抑制微环境的分子机制
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[塚本信夫, 長谷川豪, 永濱康晴, 大波陽子, 河上裕, Kawakami Y, Kawakami Y]
通讯作者:
Kawakami Y
共 113 条
Investigation of differential immune status among cancer patients and development of personalized cancer therapy by combining immunomodulation
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批准号:26221005
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$124.88万
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财政年份:2014
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负责人:KAWAKAMI Yutaka
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依托单位:
Systematic analysis of cellular signaling involved in the melanoma induced immunosuppression
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批准号:25670506
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2013
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负责人:KAWAKAMI Yutaka
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依托单位:
Development of effective immunotherapy by combining interventions on key points in the anti-tumor immune network
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批准号:23240128
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.37万
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财政年份:2011
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负责人:KAWAKAMI Yutaka
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依托单位:
Investigation of roles of miRNA in the immunosuppression and clinical use for patients with melanoma
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批准号:23659554
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:KAWAKAMI Yutaka
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依托单位:
Development of effective immunotherapy by combining methods to restore immunocompetence of cancer patients
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批准号:19390355
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2007
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负责人:KAWAKAMI Yutaka
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依托单位:
Development of new diagnostic and immunotherapeutic methods for patients with cancer
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批准号:14104013
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$70.14万
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财政年份:2002
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负责人:KAWAKAMI Yutaka
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依托单位:
Systematic isolation of genes encoding candidate proteins for human melanoma antigens using serial analysis of gene expression (SAGE) and EST database
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批准号:12470180
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2000
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负责人:KAWAKAMI Yutaka
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依托单位:
Development of diagnositic and therapeutic methods using frameshift mutated peptides for colorectal cancers with microsatellite instability
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批准号:12557109
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2000
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负责人:KAWAKAMI Yutaka
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依托单位:
Isolation of human melanoma antigens recognized bt T cells for development of immunotherapy and gene therapy
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批准号:10557083
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.7万
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财政年份:1998
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负责人:KAWAKAMI Yutaka
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依托单位:
Isolation of human tumor antigens recognized by antibodies for development of immunotherapy and gene therapy
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批准号:10470264
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.38万
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财政年份:1998
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负责人:KAWAKAMI Yutaka
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依托单位:
海外基金