A crosstalk between Toll-like receptor and C-type lectin

Toll样受体与C型凝集素之间的串扰

• 批准号: 19390477
• 负责人: SHIBATA Kenichiro
• 金额: $ 12.15万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390477/
• 关键词: 免疫; 感染; 炎症; FSL-1; TLR2; DC-SIGN; XS106細胞; リポアラビノマンナン; MDDC; Man_9(GLcNAc)_2

Hosts recognize microbial invasion and then kill them intracellularily. In this study, we demonstrated that the signal mediated by a sensor that recognize bacterial invasion was suppressed by that by phagocytic receptor.

微生物识别微生物入侵，然后在细胞内杀死它们。在这项研究中，我们证明了由识别细菌入侵的传感器介导的信号被吞噬受体所抑制。

项目成果

9件)(1)柴田健一郎.マイコプラズマ由来リポタンパク質-リポペプチドのユニークな生物活性

9个结果）（1）支原体脂蛋白和脂肽的独特生物活性。

• 发表时间: 2009
• 作者: Yamazaki K;Honda T;Domon H;Okui T;Kajita K;Amanuma R;Kudoh C;Takashiba S;Kokeguchi S;Nishimura F;Ko M;Aizawa Y;Oda H;柴田健一郎
• 通讯作者: 柴田健一郎

Reseveratrol modulates phagocytosis of bacteria through an NF-κB-dependent gene program.

白藜芦醇通过 NF-κB 依赖性基因程序调节细菌的吞噬作用。

• 发表时间: 2008
• 期刊: Antimicrobial Agents Chemotherapy 52
• 作者: M Iyori;H Kataoka;H M Shamsul;K Kiura;T Nakata;A Hasebe;M Yasuda;and K Shibata*.
• 通讯作者: and K Shibata*.

Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses

• DOI: 10.1128/mcb.01412-07
• 发表时间: 2008-02-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Into, Takeshi;Inomata, Megumi;Matsushita, Kenji
• 通讯作者: Matsushita, Kenji

Anti-and pro-tumor activities of the TLR2 ligand FSL-1

TLR2 配体 FSL-1 的抗肿瘤和促肿瘤活性

• 发表时间: 2009
• 作者: K Shibata;K Kiura;A Hasebe;M Iyori;MS Haque;M Ohtani
• 通讯作者: M Ohtani

Resveratrol modulates phagocytosis of bacteria through an NF-κB-dependent gene program

• DOI: 10.1128/aac.00210-07
• 发表时间: 2008-01-01
• 期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
• 影响因子: 4.9
• 作者: Iyori, Mitsuhiro;Kataoka, Hideo;Shibata, Ken-ichiro
• 通讯作者: Shibata, Ken-ichiro