Study of neurite elongation mechanisms of early-late endosome transfer

我们研究了Solo、Rho GT3和C类VPS/HOPS分子调控的早-晚内体转换控制神经突起伸长的细胞内机制。我们发现Rac是Solo诱导的神经突起伸长的主要下游信号调节因子，VPS 39在细胞信号转导中起重要作用。此外，我们建立了一种新的在体生物测定神经突起的伸长/神经再生的大鼠面神经与硅管结扎。

We studied on the intracellular mechanisms of neurite elongation controlled by early-late endosome transition modulated by Solo, Rho GTPase and class C VPS/HOPS molecules. We found that Rac is a major downstream signal regulator for neurite elongation induced by Solo and that VPS39 plays an important role in the cellular signal transduction. Moreover, we established a novel in vivo bioassay for neurite elongation/nerve regeneration by ligation of dissected rat facial nerve with silicon tube.