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Study of neurite elongation mechanisms of early-late endosome transfer

Study of neurite elongation mechanisms of early-late endosome transfer
早期-晚期内体转移的神经突伸长机制研究
批准号:
19500338
负责人:
AOKI Shunsuke
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
We studied on the intracellular mechanisms of neurite elongation controlled by early-late endosome transition modulated by Solo, Rho GTPase and class C VPS/HOPS molecules. We found that Rac is a major downstream signal regulator for neurite elongation induced by Solo and that VPS39 plays an important role in the cellular signal transduction. Moreover, we established a novel in vivo bioassay for neurite elongation/nerve regeneration by ligation of dissected rat facial nerve with silicon tube.
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DOI: 10.1093/hmg/ddn037
发表时间: 2008-05-15
期刊: HUMAN MOLECULAR GENETICS
影响因子: 3.5
作者: [Kabuta, Tomohiro, Setsuie, Rieko, Wada, Keiji]
通讯作者: Wada, Keiji
DOI: 10.1111/j.1460-9568.2008.06026.x
发表时间: 2008-02-01
期刊: EUROPEAN JOURNAL OF NEUROSCIENCE
影响因子: 3.4
作者: [Sasaki, Ryo, Aoki, Shunsuke, Ogiuchi, Hideki]
通讯作者: Ogiuchi, Hideki
DOI: 10.1016/j.neuint.2008.12.005
发表时间: 2009-05-01
期刊: NEUROCHEMISTRY INTERNATIONAL
影响因子: 4.2
作者: [Kimiwada, Tomomi, Sakurai, Mikako, Wada, Keiji]
通讯作者: Wada, Keiji
DOI: 10.1111/j.1471-4159.2006.04339.x
发表时间: 2007-04-01
期刊: JOURNAL OF NEUROCHEMISTRY
影响因子: 4.7
作者: [Noda, Mami, Kariura, Yukihiro, Wada, Keiji]
通讯作者: Wada, Keiji
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