Study of neurite elongation mechanisms of early-late endosome transfer

早期-晚期内体转移的神经突伸长机制研究

• 批准号: 19500338
• 负责人: AOKI Shunsuke
• 金额: $ 2.41万
• 依托单位: Kyushu Institute of Technology (2008-2009)National Center of Neurology and Psychiatry (2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500338/
• 关键词: 神経損傷の再生・修復; 細胞内小胞輸送; Solo; class C VPS; HOP; 神経突起伸長; Rho small GTPaseファミリー; エンドソーム; Rho small GTPase ファミリー

We studied on the intracellular mechanisms of neurite elongation controlled by early-late endosome transition modulated by Solo, Rho GTPase and class C VPS/HOPS molecules. We found that Rac is a major downstream signal regulator for neurite elongation induced by Solo and that VPS39 plays an important role in the cellular signal transduction. Moreover, we established a novel in vivo bioassay for neurite elongation/nerve regeneration by ligation of dissected rat facial nerve with silicon tube.

我们研究了Solo、Rho GT3和C类VPS/HOPS分子调控的早-晚内体转换控制神经突起伸长的细胞内机制。我们发现Rac是Solo诱导的神经突起伸长的主要下游信号调节因子，VPS 39在细胞信号转导中起重要作用。此外，我们建立了一种新的在体生物测定神经突起的伸长/神经再生的大鼠面神经与硅管结扎。

项目成果

Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1

• DOI: 10.1093/hmg/ddn037
• 发表时间: 2008-05-15
• 期刊: HUMAN MOLECULAR GENETICS
• 影响因子: 3.5
• 作者: Kabuta, Tomohiro;Setsuie, Rieko;Wada, Keiji
• 通讯作者: Wada, Keiji

Neurosphere generation from dental pulp of adult rat incisor

• DOI: 10.1111/j.1460-9568.2008.06026.x
• 发表时间: 2008-02-01
• 期刊: EUROPEAN JOURNAL OF NEUROSCIENCE
• 影响因子: 3.4
• 作者: Sasaki, Ryo;Aoki, Shunsuke;Ogiuchi, Hideki
• 通讯作者: Ogiuchi, Hideki

Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells

• DOI: 10.1016/j.neuint.2008.12.005
• 发表时间: 2009-05-01
• 期刊: NEUROCHEMISTRY INTERNATIONAL
• 影响因子: 4.2
• 作者: Kimiwada, Tomomi;Sakurai, Mikako;Wada, Keiji
• 通讯作者: Wada, Keiji

UCH-Lファミリー分子群を標的としたin silicoドッキング・シミュレーションによる新規作用薬剤の同定

通过针对 UCH-L 家族分子的计算机对接模拟识别新型药物

• 发表时间: 2007
• 作者: 柳澤比呂子;豊田雅士;元山純;吉田瞳;中野芳朗;川野仁;山元大輔;三五一憲;青木 俊介
• 通讯作者: 青木 俊介

Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microglia

• DOI: 10.1111/j.1471-4159.2006.04339.x
• 发表时间: 2007-04-01
• 期刊: JOURNAL OF NEUROCHEMISTRY
• 影响因子: 4.7
• 作者: Noda, Mami;Kariura, Yukihiro;Wada, Keiji
• 通讯作者: Wada, Keiji