Role of arachidonic acid cascade in regulating nociceptive transmission in the rat spinal dorsal horn

花生四烯酸级联在调节大鼠脊髓背角伤害性传递中的作用

• 批准号: 19500351
• 负责人: KUMAMOTO Eiichi
• 金额: $ 3万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500351/
• 关键词: メリチン; ホスホリパーゼA_2; アラキドン酸カスケード; 脊髄後角; 抑制性シナプス伝達; IPSC; パッチクランプ法; 痛覚情報伝達; ホスホリパーゼA2

ホスホリパーゼA_2(PLA_2)の活性化ペプチドであるメリチンを用い、痛み伝達の制御に重要な役割を果たす脊髄後角膠様質ニューロンのGABA およびグリシンを介する抑制性シナプス伝達がPLA2活性化により促進されることを発見した。前者の促進は興奮性シナプス伝達の促進を介したアセチルコリンやノルアドレナリンの作用による一方、後者の促進はグリシンシナプスでのアラキドン酸のリポキシゲナーゼ代謝物の作用によることを明らかにした。

The activation of PLA_2 (PLA_2) was promoted by inhibiting the activation of PLA_2 in the presence of GABA and the activation of PLA_2 in the presence of GABA. The former promotes the action of excitatory substances and the latter promotes the action of excitatory substances and metabolites.

项目成果

Relationship between inhibition by opioids of compound action potentials in frog sciatic nerves and their chemical structures.

阿片类药物对青蛙坐骨神经复合动作电位的抑制与其化学结构的关系。

• 发表时间: 2008
• 作者: M. Kosugi;T. Nakatsuka;T. Fujita;T. Aoyama;E. Kumamoto;Masafumi Kosugi;中塚映政;熊本 栄一;中塚 映政;C.-Y. Jiang;Chang-Yu Jiang;Kotaro Mizuta
• 通讯作者: Kotaro Mizuta

Effect of resiniferatoxin on excitatory synaptic transmission in adultrat substantia gelatinosa neurons.

树脂毒素对成年大鼠胶质质神经元兴奋性突触传递的影响。

• 发表时间: 2008
• 作者: M. Kosugi;T. Nakatsuka;T. Fujita;T. Aoyama;E. Kumamoto;Masafumi Kosugi;中塚映政;熊本 栄一;中塚 映政;C.-Y. Jiang;Chang-Yu Jiang;Kotaro Mizuta;T. Liu;C.-Y. Jiang;H.-Y. Yue;T. Fujita;Tsugumi Fujita;Hai-Yuan Yue;Chang-Yu Jiang;Tao Liu;Terumasa Nakatsuka;Daisuke Tomohiro;Kotaro Mizuta;Toshifumi Kosugi;T. Fujita;Tsugumi Fujita;H.-Y. Yue;Hal-Yuan Yue;E. Kumamoto;Eiichi Kumamoto;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Terumasa Nakatsuka;T. Nakatsuka;T. Liu;H.-Y. Yue;Toshifumi Kosugi;Hai-Yuan Yue;Tao Liu;Terumasa Nakatsuka;H.-Y. Yue;C.-Y. Jiang;T. Liu;L.-H. Piao;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Daisuke Tomohiro;Kotaro Mizuta;Toshifumi Kosugi;Terumasa Nakatsuka;Lian-Hua Piao;Tao Liu;Chang-Yu Jiang
• 通讯作者: Chang-Yu Jiang

Galanin modulates excitatory synaptic transmission in rat substantia gelatinosa neurons

甘丙肽调节大鼠胶质质神经元的兴奋性突触传递

• 发表时间: 2008
• 作者: M. Kosugi;T. Nakatsuka;T. Fujita;T. Aoyama;E. Kumamoto;Masafumi Kosugi;中塚映政;熊本 栄一;中塚 映政;C.-Y. Jiang;Chang-Yu Jiang;Kotaro Mizuta;T. Liu;C.-Y. Jiang;H.-Y. Yue;T. Fujita;Tsugumi Fujita;Hai-Yuan Yue;Chang-Yu Jiang;Tao Liu;Terumasa Nakatsuka;Daisuke Tomohiro;Kotaro Mizuta;Toshifumi Kosugi;T. Fujita;Tsugumi Fujita;H.-Y. Yue;Hal-Yuan Yue;E. Kumamoto;Eiichi Kumamoto;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Terumasa Nakatsuka;T. Nakatsuka;T. Liu;H.-Y. Yue;Toshifumi Kosugi;Hai-Yuan Yue;Tao Liu;Terumasa Nakatsuka;H.-Y. Yue;C.-Y. Jiang;T. Liu;L.-H. Piao;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Daisuke Tomohiro;Kotaro Mizuta;Toshifumi Kosugi;Terumasa Nakatsuka;Lian-Hua Piao;Tao Liu;Chang-Yu Jiang;Hai-Yuan Yue;T. Aoyama;Takahiro Aoyama;T. Nakatsuka;H.-Y. Yue;L.-H. Piao;T. Liu;T. Fujita;Tsugumi Fujita;Daisuke Tomohiro;Toshifumi Kosugi;Tao Liu;Lian-Hua Piao;Hai-Yuan Yue;Terumasa Nakatsuka;T. Nakatsuka;H.-Y. Yue
• 通讯作者: H.-Y. Yue

ATP受容体の活性化による脊髄運動ニューロンの興奮

通过激活 ATP 受体来激发脊髓运动神经元

• 发表时间: 2008
• 作者: M. Kosugi;T. Nakatsuka;T. Fujita;T. Aoyama;E. Kumamoto;Masafumi Kosugi;中塚映政;熊本 栄一;中塚 映政;C.-Y. Jiang;Chang-Yu Jiang;Kotaro Mizuta;T. Liu;C.-Y. Jiang;H.-Y. Yue;T. Fujita;Tsugumi Fujita;Hai-Yuan Yue;Chang-Yu Jiang;Tao Liu;Terumasa Nakatsuka;Daisuke Tomohiro;Kotaro Mizuta;Toshifumi Kosugi;T. Fujita;Tsugumi Fujita;H.-Y. Yue;Hal-Yuan Yue;E. Kumamoto;Eiichi Kumamoto;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Terumasa Nakatsuka;T. Nakatsuka;T. Liu;H.-Y. Yue;Toshifumi Kosugi;Hai-Yuan Yue;Tao Liu;Terumasa Nakatsuka;H.-Y. Yue;C.-Y. Jiang;T. Liu;L.-H. Piao;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Daisuke Tomohiro;Kotaro Mizuta;Toshifumi Kosugi;Terumasa Nakatsuka;Lian-Hua Piao;Tao Liu;Chang-Yu Jiang;Hai-Yuan Yue;T. Aoyama;Takahiro Aoyama;T. Nakatsuka;H.-Y. Yue;L.-H. Piao;T. Liu;T. Fujita;Tsugumi Fujita;Daisuke Tomohiro;Toshifumi Kosugi;Tao Liu;Lian-Hua Piao;Hai-Yuan Yue;Terumasa Nakatsuka;T. Nakatsuka;H.-Y. Yue;T. Liu;L.-H. Piao;T. Aoyama;T. Fujita;Tsugumi Fujita;Takahiro Aoyama;Lian-Hua Piao;Tao Liu;Hai-Yuan Yue;Terumasa Nakatsuka;Daisuke Tomohiro;岳海源;青山貴博
• 通讯作者: 青山貴博

Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems, Ed.by E.Kumamoto

周围和中枢神经系统伤害感受传递调节的细胞和分子机制，E.Kumamoto 编

• 发表时间: 2007
• 作者: M. Kosugi;T. Nakatsuka;T. Fujita;T. Aoyama;E. Kumamoto;Masafumi Kosugi;中塚映政;熊本 栄一;中塚 映政;C.-Y. Jiang;Chang-Yu Jiang;Kotaro Mizuta;T. Liu;C.-Y. Jiang;H.-Y. Yue;T. Fujita;Tsugumi Fujita;Hai-Yuan Yue;Chang-Yu Jiang;Tao Liu;Terumasa Nakatsuka;Daisuke Tomohiro;Kotaro Mizuta;Toshifumi Kosugi;T. Fujita;Tsugumi Fujita;H.-Y. Yue;Hal-Yuan Yue;E. Kumamoto;Eiichi Kumamoto;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Terumasa Nakatsuka;T. Nakatsuka;T. Liu;H.-Y. Yue;Toshifumi Kosugi;Hai-Yuan Yue;Tao Liu;Terumasa Nakatsuka;H.-Y. Yue;C.-Y. Jiang;T. Liu;L.-H. Piao;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Daisuke Tomohiro;Kotaro Mizuta;Toshifumi Kosugi;Terumasa Nakatsuka;Lian-Hua Piao;Tao Liu;Chang-Yu Jiang;Hai-Yuan Yue;T. Aoyama;Takahiro Aoyama;T. Nakatsuka;H.-Y. Yue;L.-H. Piao;T. Liu;T. Fujita;Tsugumi Fujita;Daisuke Tomohiro;Toshifumi Kosugi;Tao Liu;Lian-Hua Piao;Hai-Yuan Yue;Terumasa Nakatsuka;T. Nakatsuka;H.-Y. Yue;T. Liu;L.-H. Piao;T. Aoyama;T. Fujita;Tsugumi Fujita;Takahiro Aoyama;Lian-Hua Piao;Tao Liu;Hai-Yuan Yue;Terumasa Nakatsuka;Daisuke Tomohiro;岳海源;青山貴博;熊本栄一;熊本 栄一;中塚映政;T. Liu;A. Koga;T. Nakatsuka;T. Fujita;Tsugumi Fujita;Terumasa Nakatsuka;Akiko Koga;Tao Liu;T. Aoyama;Takahiro Aoyama;Kotaro Mizuta;Kotaro Mizuta;M. Kosugi;Ryo Katsuki;Masafumi Kosugi;T. Liu;T. Fujita;Tsugumi Fujita;Tao Liu;T. Fujita;M. Kosugi;Kotaro Mizuta;Masafumi Kosugi;Tsugumi Fujita;前田正信 監訳;E. Kumamoto;T. Nakatsuka;T. Fujita;Eiichi Kumamoto;Terumasa Nakatsuka
• 通讯作者: Terumasa Nakatsuka