Anti-allergic effect of Kampo medicine : a possible association with enteric microbiota and gastrointestinal immune system
Anti-allergic effect of Kampo medicine : a possible association with enteric microbiota and gastrointestinal immune system
批准号:
19590701
负责人:
WATANABE Kenji
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
漢方薬はアレルギー性疾患によく用いられるが、その作用に、腸内環境の変化を伴うものである、という仮説のもとに研究を進めた。幼少時から抗生剤投与を行うことにより、正常な免疫の発達が阻害された。腸内細菌の攪乱とアレルギー体質との関連を探るために、無菌マウスへ腸内細菌を移植して網羅的遺伝子発現解析を行い、出生直後の無菌状態がTh1/Th2分化を決定付ける転写因子の発現異常をもたらすことを明らかにした。
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C57BL/6マウス大腸のtype1インターフェロン産生における十全大補湯の影響
Juzentaihoto 对 C57BL/6 小鼠结肠中 1 型干扰素产生的影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[宗形 佳織, 高嶋 清江, 山本 雅浩, 渡辺 賢治, ら]
通讯作者:
ら
慶應義塾大学医学部漢方医学センターHP
庆应义塾大学医学院中医中心 HP
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
The effect of a herbal medicine (Juzen-taiho-to) in the large intestine implications for mechanism of prevention of infection
草药(Juzen-taiho-to)在大肠中的作用对预防感染机制的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Munakata K, Takashima K, Yamamoto M, Ishige A, Watanabe K.]
通讯作者:
Watanabe K.
腸管におけるI型インターフェロン(IFN)の産生-十全大補湯の研究から-
肠道中 I 型干扰素 (IFN) 的产生 - 来自 Juzentaihoto 的研究 -
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[木村 文治, ら, 宗形佳織]
通讯作者:
宗形佳織
C57BL/6マウス大腸のtype 1インターフェロン産生における十全大補湯の影響
Juzentaihoto 对 C57BL/6 小鼠结肠中 1 型干扰素产生的影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[宗形佳織, 高嶋清江, 山本雅浩, 渡辺賢治]
通讯作者:
渡辺賢治
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