Where is the cause of Bartter's syndrome in the kidney?

巴特综合征的病因在肾脏哪里？

• 批准号: 19590936
• 负责人: WATANABE Sumiyo
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590936/
• 关键词: バーター症候群; カルシウム代謝; 腎機能低下; 副甲状腺機能低下症; Ca感知受容体; 腎電解質異常; 低Ca血症; 慢性腎不全; 骨異栄養症; 遺伝子治療; 遺伝子治療3; カルシウム感知受容体; 腎電解質代謝; 低カルシウム血症; 高カリウム血症; 高リン血症

We developed the expression method using tissue-specific promoters and it resulted in site-specific EGFP expression within the kidney. Adenovirus expression could be limited to the thick ascending limb of Henle (TALH), proximal tubules, or collecting ducts of the kidney without causing liver expression or kidney damage. We investigated it using GFP protein, and next, we tend to express calcium-sensing receptor.

我们开发了使用组织特异性启动子的表达方法，并导致了肾脏内的位点特异性EGFP表达。腺病毒表达可局限于肾的粗升支（TALH）、近端小管或集合管，而不引起肝表达或肾损伤。我们用GFP蛋白研究了它，接下来，我们倾向于表达钙敏感受体。

项目成果

Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity

• DOI: 10.1016/j.devcel.2008.03.007
• 发表时间: 2008-05-01
• 期刊: DEVELOPMENTAL CELL
• 影响因子: 11.8
• 作者: Ohba, Shinsuke;Kawaguchi, Hiroshi;Chung, Ung-il
• 通讯作者: Chung, Ung-il

Three-dimensional microenvironments retain chondrocyte phenotypes during proliferation culture.

• DOI: 10.1089/ten.2006.0322
• 发表时间: 2007-07
• 期刊: Tissue engineering
• 作者: Tsuguharu Takahashi;T. Ogasawara;Y. Asawa;Y. Mori;E. Uchinuma;T. Takato;K. Hoshi

Identification of the Core Element Responsive to Runt-Related Transcription Factor 2 in the Promoter of Human Type X Collagen Gene

• DOI: 10.1002/art.24243
• 发表时间: 2009-01-01
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Higashikawa, Akiro;Saito, Taku;Kawaguchi, Hiroshi
• 通讯作者: Kawaguchi, Hiroshi

Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator

• DOI: 10.1016/j.gene.2008.03.003
• 发表时间: 2008-06-15
• 期刊: GENE
• 影响因子: 3.5
• 作者: Tamiya, Hiroyuki;Ikeda, Toshiyuki;Choi, Je-Yong
• 通讯作者: Choi, Je-Yong

Podocyte foot process effacement in very early phase of passive Heymann nephritis is not a prerequisite for proteinuria

被动海曼肾炎早期足细胞足突消失并不是蛋白尿的先决条件

• 发表时间: 2009
• 期刊: J Nephrol. Jul-Aug ; 22(4)
• 作者: Nosaka H;Uchida S;et.al
• 通讯作者: et.al