The effect of α2-adrenergic agonist on chemokine expression in human retinal pigment epithelial cells
The effect of α2-adrenergic agonist on chemokine expression in human retinal pigment epithelial cells
批准号:
19791259
负责人:
WATANABE Kazuhiko
金额:
$1.27万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
網膜色素上皮細胞においてADR-α2 mRNAの発現が認められた。VEGF mRNA及び蛋白質の発現はIL-1β刺激で増加し、クロニジンはその発現を有意に抑制した。その作用機序はp38MAPKとMEK1/2シウナル伝達系を介して抑制していることを明らかにした。Clonidineは脈絡膜新生血管膜あるいは血管新生を生じる、一部の眼疾患において有効である可能性が示唆された。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1007/s00417-008-0990-5
发表时间:
2009-01
期刊:
Graefe's Archive for Clinical and Experimental Ophthalmology
影响因子:
--
作者:
[Kazuhiko Watanabe;Xue-Yun Zhang;K. Kitagawa;Tatsuya Yunoki;A. Hayashi]
通讯作者:
Kazuhiko Watanabe;Xue-Yun Zhang;K. Kitagawa;Tatsuya Yunoki;A. Hayashi
ヒト網膜色素上皮細胞でのIL-1βによるVEGF産生に対するClonidineの影響
可乐定对人视网膜色素上皮细胞IL-1β产生VEGF的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[張学云, 渡辺一彦, 林篤志]
通讯作者:
林篤志
Evaluation of dynamic balance and set up the program for developing the function : focusing on COP
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批准号:21500597
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
-
财政年份:2009
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负责人:WATANABE Kazuhiko
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依托单位:
Ground reaction force and its feeling during walk in middle and elderly :focused on walking speed and carrying weight
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批准号:18500464
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.53万
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财政年份:2006
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负责人:WATANABE Kazuhiko
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依托单位:
A study on the best motion of ski jumping in take off phase : An analysis of feeling of pressure from the ground
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批准号:16500408
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:WATANABE Kazuhiko
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依托单位:
A study on increasing a function of the gait movement in elderly
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批准号:12680032
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2000
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负责人:WATANABE Kazuhiko
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依托单位:
Research project on educational topics from a view point of women's life cycle : application to the "Shoshika" and "Kohreika"
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批准号:09045009
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$3.07万
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财政年份:1997
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负责人:WATANABE Kazuhiko
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依托单位:
Study on safety education to elderly person during walking down a stair.
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批准号:07458017
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.29万
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财政年份:1995
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负责人:WATANABE Kazuhiko
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依托单位:
A basic study of gait analysis in aged prsons
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批准号:04680129
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1992
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负责人:WATANABE Kazuhiko
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依托单位:
海外基金