Identification of expression and localization of osteoclast-specific ABC transporters
Identification of expression and localization of osteoclast-specific ABC transporters
批准号:
19791361
负责人:
NAKAGAWA Hiroshi
金额:
$2.31万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
The expression of nine and four of 49 ABC transporters were found to be up- and down-regulated during osteoclastgenesis, respectively. It was also found that the expression levels and distribution of ABCG2 were regulated by single nucleotide polymorphisms and posttranslational modifications, which was awarded the Special ABC2010 Poster Recognition Award.
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The impact of N-linked glycosylation on the protein stability of human ABC transporter ABCG2 protein
N联糖基化对人ABC转运蛋白ABCG2蛋白稳定性的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., Ishikawa, T]
通讯作者:
T
Evidence for ubiquitination and degradation of non-synonymous SNPproteins ofhuman ATP-binding cassette transporter ABCG2.
人 ATP 结合盒转运蛋白 ABCG2 的非同义 SNP 蛋白泛素化和降解的证据。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Nakagawa, H., Tamura, A., Wakabayashi, K., Ishikawa, T, Hiroshi Nakagawa]
通讯作者:
Hiroshi Nakagawa
ヒトABCトランスポーターABCG2のタンパク質品質管理と細胞内分解機構:一塩基多型と翻訳後修飾の影響
人ABC转运蛋白ABCG2的蛋白质质量控制和细胞内降解机制:单核苷酸多态性和翻译后修饰的影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[中川大, 若林香菜子, 田村藍, 星島一幸, 石川智久]
通讯作者:
石川智久
ヒトABCトランスポーターの遺伝子多型研究の最前線ABCBl (P-gp/MDRl), ABCG2 (BCRP/MXR), ABCBll (BSEP).
人类ABC转运蛋白基因多态性研究前沿:ABCB1(P-gp/MDRl)、ABCG2(BCRP/MXR)、ABCBll(BSEP)。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[中川大, 若林香菜子, 田村藍, 星島一幸, 石川智久, 中川 大, 石川 智久]
通讯作者:
石川 智久
Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of human ATP-binding cassette transporter ABCG2.
N 连接糖基化的破坏增强了泛素介导的人 ATP 结合盒转运蛋白 ABCG2 的蛋白酶体降解。
DOI:
--
发表时间:
2009
期刊:
FEBS J. 276
影响因子:
--
作者:
[Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., Ishikawa, T.]
通讯作者:
T.
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