The development innovative treatment of oral cancer by photodynamic therapy, and basic research.
The development innovative treatment of oral cancer by photodynamic therapy, and basic research.
批准号:
21791965
负责人:
NAKAGAWA Hiroshi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
口腔白斑和扁平苔藓属于癌前病变,长期复发率高,治疗方法尚未确立。肿瘤的高复发率提示血管生成因子的表达。我们研究了NPe6介导的PDT的抗肿瘤作用,抑制了血管生成因子的表达,从而确定了促进新生血管生成的基因和蛋白,并抑制了细胞的增殖、迁移和管腔形成。
英文摘要
Leukoplakia and lichen planus in oral cavity are premalignant lesions, which are high rate recurrence in a long term, and the way of treatment has not established. The high rate of recurrence was suggested that the expression of angiogenesis factor. We investigated antitumor effect by NPe6 mediated PDT, inhibited the expression of angiogenesis factor.As a result, we identified the gene and protein that contributes neoangiogenesis, and inhibited cell proliferation, migration, lumen formation.
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作者:
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通讯作者:
Development of a novel therapeutic approach targeting gingipain for regression phenomenon in Down syndrome
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批准号:20K10204
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2020
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负责人:NAKAGAWA Hiroshi
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依托单位:
Study on the relationship among nutrients, ABC transporters and locomotive system
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批准号:16K00879
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2016
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负责人:NAKAGAWA Hiroshi
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依托单位:
Development of the new molecular target therapy for wound healing of oral mucosa
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批准号:16K11805
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2016
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负责人:NAKAGAWA Hiroshi
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依托单位:
A Study of Privacy Protection in Information Retrieval
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批准号:15H02700
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2015
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负责人:NAKAGAWA Hiroshi
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依托单位:
Preventing A False Light Caused by k-anonymity with Mathematical Modling and Optimization
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批准号:26540041
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:NAKAGAWA Hiroshi
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依托单位:
Development of the new molecular target therapy for phenytoin-induced gingival overgrowth using the antagonist of TRPA1 channel
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批准号:25463180
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2013
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负责人:NAKAGAWA Hiroshi
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依托单位:
Comprehensive analysis of the relationship between the function of ABC transporters and bone metabolism; from the view point of osteoclast generation and function
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批准号:24592822
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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负责人:NAKAGAWA Hiroshi
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依托单位:
A Study on Differential Privacy for Data Base with Correlation
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批准号:24650064
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:NAKAGAWA Hiroshi
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依托单位:
Descriptive Study of Mukawa Dialect of Ainu using Recorded Materials
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批准号:23320080
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.74万
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财政年份:2011
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负责人:NAKAGAWA Hiroshi
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依托单位:
Proposal of a new phonological unit of phonological typology
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批准号:23652082
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.16万
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财政年份:2011
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负责人:NAKAGAWA Hiroshi
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依托单位:
Chemical physics of water detemining food preservation and texture
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批准号:23650469
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:NAKAGAWA Hiroshi
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依托单位:
Development ofa new dental local anesthetic and apply for the needless syringe (SYRIJET)
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批准号:22592289
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2010
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负责人:NAKAGAWA Hiroshi
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依托单位:
Validation of the expression and function of Abca5 in osteoclasts and bone tissue.
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批准号:22791786
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2010
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负责人:NAKAGAWA Hiroshi
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依托单位:
A STUDY OF RESOLVING LONG TAIL PHENOMENA BY MACHINE LEARNING
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批准号:21240011
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.12万
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财政年份:2009
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负责人:NAKAGAWA Hiroshi
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依托单位:
Effect of hydration and cavity on protein dynamics studied by neutron scattering and simulation
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批准号:21770178
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$3.0万
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财政年份:2009
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负责人:NAKAGAWA Hiroshi
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依托单位:
Identification of expression and localization of osteoclast-specific ABC transporters
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批准号:19791361
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.31万
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财政年份:2007
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负责人:NAKAGAWA Hiroshi
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依托单位:
A Study for Knowledge ExtractionAid System from Web Text
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批准号:17200007
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$27.79万
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财政年份:2005
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负责人:NAKAGAWA Hiroshi
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依托单位:
Modeling and Prediction of the Occurrence of Chalky Grains in Rice
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批准号:16380019
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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财政年份:2004
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负责人:NAKAGAWA Hiroshi
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依托单位:
Study on Language Contacts among Northern Peoples to Japan centering on Ainu from the Viewpoint of their Mingu
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批准号:15401012
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2003
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负责人:NAKAGAWA Hiroshi
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依托单位:
A Study about automatic domain term extraction from corpus
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批准号:12680368
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2000
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负责人:NAKAGAWA Hiroshi
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依托单位:
国内基金
海外基金
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