Effect of obesity and ageing on lingual muscle

肥胖和衰老对舌肌的影响

• 批准号: 19791550
• 负责人: SAITOU Takashi
• 金额: $ 1.66万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791550/
• 关键词: 生理学; 歯学; 口腔外科学; 発生; 分化; 病理; 肥満; 加齢; 舌筋; 閉塞性睡眠時無呼吸症候群; ラット; 発生、分化

The purposes of the present study were to elucidate influences of obesity on the property and volume of lingual (genioglossus and geniohyoid) muscles and to relate the changes with the structure and volume of upper airway in the obese rats. We analyzed the accumulation of triaclyglycerol and the diameter of myofibers in the lingual muscles with histochemistry, the MyHC composition with real-time PCR and the structure and volume of upper airway with μCT in the rats after feeding a high fat diet for 10 weeks. In the genioglossus and geniohyoid muscles, the percentage of oil droplet areas in the obesity group were 3.6- and 2.5- greater in comparison with those in the control group respectively (p<0.05). The diameters of slow myofibers in the genioglossus and geniohyoid muscles were approximately 20% greater in the obesity group than the control group (p<0.0001), while that of fast myofibers in geniohyoid muscle was approximately 10% greater in the obesity group than the control group (p<0.001). The volume of upper airway in the obesity group was 12% greater than in the normal group (p<0.05). These results suggest that the volume of upper airway was associated with the structure of lingual (genioglossus and geniohyoid) muscles.

本研究的目的是阐明肥胖对舌（Genioglossus and Geniohyoid）肌肉的特性和体积的影响，并将变化与肥胖大鼠的上呼吸道的结构和体积联系起来。我们分析了三甘油甘油的积累和肌纤维的直径在舌肌中具有组织化学，带有实时PCR的MYHC组成以及在喂养高脂肪饮食后，大鼠中带有μCT的上呼吸道的结构和体积。在Genioglossus和Geniohyoid肌肉中，与对照组相比，肥胖组的油滴面积的百分比分别为3.6和2.5-（P <0.05）。肥胖组的Genioglossus和Geniohoid肌肉中缓慢的肌纤维直径比对照组高约20％（p <0.0001），而肥胖组的基因透明肌肉中快速肌纤维的直径比对照组高约10％（p <0.001）。肥胖组的上呼吸道体积比正常组大12％（p <0.05）。这些结果表明，上呼吸道的体积与舌（Genioglossus和Geniohyoid）肌肉的结构有关。

项目成果

肥満ラットにおける舌筋と上気道容積の変化

肥胖大鼠舌肌和上气道容积的变化

• 发表时间: 2010
• 作者: 斎藤高;山根明;小川匠;井川知子;杉崎正志
• 通讯作者: 杉崎正志

Study on Adipogenic Changes of Lingual Muscles in Obese Rat

肥胖大鼠舌肌成脂变化的研究

• 发表时间: 2009
• 作者: Takashi Saito;Akira Yamane;Syuhei Kaneko;Takumi Ogawa;Tomoko Ikawa;Akiko Shinohara;Kaori Saito;Masashi Sugisaki
• 通讯作者: Masashi Sugisaki