Association with central sensitization and descending inhibition in patients with myogenous type of temporomandibular disorder.

与肌源性颞下颌疾病患者的中枢敏化和下行抑制相关。

• 批准号: 19791542
• 负责人: MURAOKA Wataru
• 金额: $ 2.34万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791542/
• 关键词: 歯学; 遺伝子; 疼痛; 慢性筋性顎関節症; 時間的加重; セロトニン関連遺伝子

I hypothesized that the pathogenesis of myogeneous TMD had a relationship to the central sensitization and descending inhibition, and investigated by using temporal summation tests, mapping of referred pain in the masticatory muscle, and the serotonin transporter gene polymorphism.At the present stage, this study showed that myogeneous TMD cases may, in fact, be related to the central sensitization, and require longer duration of treatment in order to show improvement of signs and symptoms.The analysis of the serotonin transporter gene polymorphism was, so far, inconclusive. I will continue this study for further consideration by increasing the number of subjects.

我假设肌源性TMD的发病机制与中枢敏化和下行抑制有关，并通过时间总和检验、咀嚼肌牵涉疼痛定位和5-羟色胺转运体基因多态性进行了研究。现阶段，本研究表明，肌源性TMD实际上可能与中枢敏感化有关，需要更长的疗程才能表现出症状和体征的改善。5-羟色胺转运体基因多态性的分析迄今尚未得出结论。我将继续这项研究，通过增加受试者的数量来进一步考虑。

项目成果

The Difference of Treatment Effectiveness between Active and Latent Myofascial Trigger Point Associated with Temporomandibular Disorder.

与颞下颌疾病相关的主动肌筋膜触发点和潜在肌筋膜触发点之间的治疗效果差异。

• 发表时间: 2009
• 作者: Wataru Muraoka;Daisuke Kobayashi;Tomoko Wada;Masatsugu Otaishi;Taneaki Nakagawa;Koichi Wajima
• 通讯作者: Koichi Wajima

筋性顎関節症における活動性トリガーポイントと潜在性トリガーポイントにおける経過の違いについて.

肌肉性颞下颌关节疾病的主动和潜在触发点过程的差异。

• 发表时间: 2009
• 作者: 村岡渡;小林大輔;和田知子;佐藤仁;大泰司正嗣;中川種昭;和嶋浩一
• 通讯作者: 和嶋浩一

The Difference of Treatment Effectiveness between Active and Latent Myofascial Trigger Point Associated with Temporomandibular Disorder

颞下颌关节紊乱病相关主动肌筋膜触发点和潜在肌筋膜触发点治疗效果的差异

• 发表时间: 2009
• 作者: 村岡渡;小林大輔;和田知子;佐藤仁;大泰司正嗣;中川種昭;和嶋浩一;Wataru Muraoka
• 通讯作者: Wataru Muraoka