Mechanisms of a failure in the intestinal homeostasis and its regulation by food
Mechanisms of a failure in the intestinal homeostasis and its regulation by food
批准号:
19780104
负责人:
TAKAHASHI Kyoko
金额:
$2.3万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
腸管の恒常性の破綻に関与する過程として、腸管上皮細胞の腸内共生菌に対する過剰応答、マスト細胞の活性化の2つに着目した。前者に関しては、微生物菌体の認識に関わる分子の腸管上皮細胞特異的な転写制御機構の一端を明らかにし、後者についてはマスト細胞のアレルギー応答が菌体成分を認識する受容体の1つであるToll like receptor 2を介した刺激により抑制されることを示した。これらは、腸管の恒常性の破綻を食品成分により抑制するための標的として有用である。
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腸内細菌由来菌体成分によるマスト細胞のアレルギー応答の調節
来自肠道细菌的细菌成分调节肥大细胞过敏反应
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[相澤奉文, 高橋恭子, 笠倉和巳, 細野朗, 上野川修一]
通讯作者:
上野川修一
Suppressive effects of TLR2 ligands on allergic reactions of mast cells
TLR2配体对肥大细胞过敏反应的抑制作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[K Kasakura, K Takahashi, A Hosono, and S Kaminogawa]
通讯作者:
and S Kaminogawa
腸管上皮細胞におけるTollip遺伝子の発現制御機構
肠上皮细胞中Tollip基因表达调控机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[今野拓馬, 細野朗, 平松靖浩, 八村敏志, 高橋恭子, 上野川修一, 杉由高・高橋恭子・細野朗・上野川修一]
通讯作者:
杉由高・高橋恭子・細野朗・上野川修一
Direct effects of Lactobacillus GG and L. gasseri TMCO356 on mast cells
乳杆菌 GG 和 L.gasseri TMCO356 对肥大细胞的直接影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Harata G, Takahashi K, He F, Kubota A, Hosono A, Kaminogawa S.]
通讯作者:
Kaminogawa S.
調製法の異なるBifidobacterium菌体成分が修飾する免疫応答の特徴
不同制备方法双歧杆菌细胞成分修饰免疫反应的特点
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[平松靖浩, 細野朗, 高橋恭子, 上野川修一]
通讯作者:
上野川修一
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