Regulation of intestinal symbiotic system and inflammatory reactions by food
Regulation of intestinal symbiotic system and inflammatory reactions by food
批准号:
21780133
负责人:
TAKAHASHI Kyoko
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Interaction of intestinal commensal bacteria with mast cells and epithelial cells was analyzed. It was shown that intestinal commensal bacteria affect the terminal differentiation of mast cells and they regulate expression of the genes which are involved in recognition of microbes in intestinal epithelial cells. These mechanisms underlying modulation of the functions of mast cells and intestinal epithelial cells by commensal bacteria may provide a useful target for the regulation of inflammatory reactions which are caused by the disorder of intestinal homeostasis.
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腸管マスト細胞の数および機能への腸内細菌の影響
肠道细菌对肠道肥大细胞数量和功能的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[國井潤一, 高橋恭子, 笠倉和巳, 清野妃呂子, 細野朗, 上野川修一]
通讯作者:
上野川修一
Regulation of terminal differentiation and allergic reactions of mast cells by bacterial components.
细菌成分调节肥大细胞的终末分化和过敏反应。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kazumi Kasakura, Kyoko Takahashi, Hiroko Seino, Akira Hosono, Shuichi Kaminogawa.]
通讯作者:
Shuichi Kaminogawa.
腸内共生菌のLactobacillus及びBacteroidesの刺激によるバイエル板細胞のIgA産生における特性比較
肠道共生菌乳杆菌和拟杆菌刺激拜尔斑细胞产生 IgA 的特性比较
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[鈴木あみ, 細野朗, 大山尭人, 柳橋努, 八村敏志, 高橋宜聖, 高橋恭子, 上野川修一]
通讯作者:
上野川修一
Bacteroidesを定着させたノトバイオートマウスのパイエル板細胞は他の腸内共生菌の刺激に対しても効率的にIgA産生を誘導する
定植有拟杆菌的无菌小鼠的派尔氏补片细胞响应其他肠道共生细菌的刺激,有效诱导 IgA 产生。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大山尭人, 細野朗, 鈴木あみ, 柳橋努, 津田真人, 八村敏志, 高橋宜聖, 伊藤喜久治, 平山和宏, 高橋恭子, 上野川修一]
通讯作者:
上野川修一
Intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate the serum antibody responses induced by dietary antigen
肠道共生细菌促进 T 细胞反应低下并下调饮食抗原诱导的血清抗体反应
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Masato Tsuda, Akira Hosono, Tsutomu Yanagibashi, Satoshi Hachimura, Kikuji Itoh, Kyoko Takahashi, Shuichi Kaminogawa]
通讯作者:
Shuichi Kaminogawa
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