Study of therapeutic effects of vessel-permeable 11R protein on stroke

点击翻译按钮获取中文摘要

We made fusion proteins of 11R with superoxide-dismutase, TGF-beta、low-density lipoprotein receptor, endothelial NOS, and superoxide-dismutase by using genetic recombination technique. endothelial NOS-11R transmitted into the brain blood vessels, and it made these vessels dilated, successfully. (Stroke. 38 : 1354-61, 2007). We also revealed that 11R protein could transmit into any layers of arterial vessels, and even large molecular weight proteins could penetrate into the any layers of the vessels with 11R protein. Meanwhile, we observed no signals of 11R in the brain parenchyma.