Spoken language development in the pediatric brain and its plastic reorganization induced by deafness

目的：探讨语言视觉成分的大脑皮层加工过程及耳聋对其的影响。受试者和方法：六名学前儿童参加了这项研究。受试者按其口语交际能力的顺序被编号为1至6。在静脉注射370 MBq 18F-FDG和脑部PET扫描之间的时间段内，每个受试者被指示观看说话人的面部视频。每个耳聋儿童的皮质放射性进行了比较，一组听力正常的成年人使用在测试中的基本SPM 2模型。结果：受试者1的双侧激活皮质区最宽，是口语使用最差的受试者。相比之下，受试者6，谁是最好的使用者的口语与助听器，和正常听力组之间没有显着差异。结论：氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）与视觉语言任务的使用提供了客观的信息皮质语言网络的发展和可塑性。这种方法可以帮助参与语言前儿童的培训和教育的个人决定适当的交流方式。

Objectives : To investigate the cortical processing of the visual component of language and the effect of deafness upon this activity. Subjects and methods : Six prelingually deafened children participated in this study. The subjects were numbered 1 to 6 in the order of their spoken communication skills. In the time period between an intravenous injection of 370 MBq 18F-FDG and PET scanning of the brain, each subject was instructed to watch a video of the face of a speaking person. The cortical radioactivity of each deaf child was compared with that of a group of normal-hearing adults using at test in a basic SPM2 model. Results : The widest bilaterally activated cortical area was detected in subject 1, who was the worst user of spoken language. By contrast, there was no significant difference between subject 6, who was the best user of spoken language with a hearing aid, and the normal hearing group. Conclusions : The use of fluorodeoxyglucose positron emission tomography (FDG-PET) with a visual language task provided objective information on the development and plasticity of cortical language networks. This approach could help individuals involved in the habilitation and education of prelingually deafened children to decide upon the appropriate mode of communication.