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Objective evaluation of vertigo treatment by functional brain imaging

脑功能成像客观评价眩晕治疗效果

基本信息

批准号：
17591815
负责人：
NAITO Yasushi
金额：
$ 2.24万
依托单位：
Institute of Biological Research and Innovation
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591815/
关键词：
vertigo functional brain imaging vestibular cortex insula inferior parietal lobule caloric stimulation optokinetic stimulation PET fMRI 治療効果

项目摘要

The purpose of this study was to evaluate subjective sensation of vertigo by measuring brain activation by vestibular and optokinetic stimulation. The analysis of functional images was performed by Statistical Parametric Mapping (SPM). In normal subjects without neurological disorders, cold air irrigation in the right ear induced vertiginous sensation, and significant activation was observed in the left insula, left inferior parietal lobule (BA40), left inferior occipital gyrus (BA19/37 ; V5), right precuneus (BA7), right supplementary motor area (BA6 ; SMA), right precentral gyrus (BA11) and left cerebellar hemisphere. Small field leftward optokinetic stimulation in normal subjects activated the left primary visual cortex (BA17 ; V1), bilateral middle occipital gyms (BA19 ; V5), bilateral precuneus (BA7), left precentral gyrus (BA4) and left hippocampus. Perception of vertiginous sensation may be processed in the cortical networks involving the insula, inferior parietal lobule and SMA, while V5 and precuneus may be related to eye movements that are common to vestibular and optokinetic systems. Optokinetic stimulation in a patient with vertigo, on the other hand, significantly activated the left V1, left kingual gyrus (BA18/19 ; V5), left SMA, left precentral gyrus (BA4), right insula / inferior frontal gyms, right inferior parietal lobule (BA40), left caudate nucleus and left middle temporal gyrus (BA21), among which vestibular cortices, SMA and basal ganglia were not included in areas activated in normal subjects with identical stimulation. These results suggest that the insula and the inferior parietal lobule may play essential roles in the cortical processing of vertiginous sensation, which may be used for objective evaluation of vertigo and its treatment efficacy.

本研究的目的是通过前庭和视动刺激测量大脑激活来评估眩晕的主观感觉。功能图像分析采用统计参数图（SPM）。在无神经系统疾病的正常受试者中，右耳冷空气灌洗引起眩晕感，在左侧脑干、左侧顶下小叶（BA 40）、左侧枕下回（BA 19/37 ; V5）、右侧楔前叶（BA 7）、右侧辅助运动区（BA 6; SMA）、右侧中央前回（BA 11）和左侧小脑半球观察到显著激活。正常人小视野视动刺激激活左侧初级视皮层（BA 17; V1）、双侧枕中回（BA 19; V5）、双侧楔前叶（BA 7）、左侧中央前回（BA 4）和左侧海马。眩晕感觉的感知可能在涉及前庭、顶下小叶和SMA的皮质网络中处理，而V5和楔前叶可能与前庭和视动系统共同的眼球运动有关。另一方面，眩晕患者的视动刺激显著激活了左侧V1，左侧王回（BA 18/19 ; V5）、左侧SMA、左侧中央前回（BA 4）、右侧额下回、右侧顶下小叶（BA 40）、左侧尾状核和左侧颞中回（BA 21），其中前庭皮质、SMA和基底神经节不包括在具有相同刺激的正常受试者中激活的区域中。结果提示，小脑顶叶和顶下小叶可能在眩晕感觉的皮层加工过程中起重要作用，可用于眩晕的客观评价和疗效观察。