Objective evaluation of vertigo treatment by functional brain imaging

脑功能成像客观评价眩晕治疗效果

基本信息

批准号：
17591815
负责人：
NAITO Yasushi
金额：
$ 2.24万
依托单位：
Institute of Biological Research and Innovation
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591815/
关键词：
vertigo functional brain imaging vestibular cortex insula inferior parietal lobule caloric stimulation optokinetic stimulation PET fMRI 治療効果

项目摘要

The purpose of this study was to evaluate subjective sensation of vertigo by measuring brain activation by vestibular and optokinetic stimulation. The analysis of functional images was performed by Statistical Parametric Mapping (SPM). In normal subjects without neurological disorders, cold air irrigation in the right ear induced vertiginous sensation, and significant activation was observed in the left insula, left inferior parietal lobule (BA40), left inferior occipital gyrus (BA19/37 ; V5), right precuneus (BA7), right supplementary motor area (BA6 ; SMA), right precentral gyrus (BA11) and left cerebellar hemisphere. Small field leftward optokinetic stimulation in normal subjects activated the left primary visual cortex (BA17 ; V1), bilateral middle occipital gyms (BA19 ; V5), bilateral precuneus (BA7), left precentral gyrus (BA4) and left hippocampus. Perception of vertiginous sensation may be processed in the cortical networks involving the insula, inferior parietal lobule and SMA, while V5 and precuneus may be related to eye movements that are common to vestibular and optokinetic systems. Optokinetic stimulation in a patient with vertigo, on the other hand, significantly activated the left V1, left kingual gyrus (BA18/19 ; V5), left SMA, left precentral gyrus (BA4), right insula / inferior frontal gyms, right inferior parietal lobule (BA40), left caudate nucleus and left middle temporal gyrus (BA21), among which vestibular cortices, SMA and basal ganglia were not included in areas activated in normal subjects with identical stimulation. These results suggest that the insula and the inferior parietal lobule may play essential roles in the cortical processing of vertiginous sensation, which may be used for objective evaluation of vertigo and its treatment efficacy.

这项研究的目的是通过通过前庭和光反性刺激测量脑激活来评估眩晕的主观感觉。功能图像的分析是通过统计参数映射（SPM）进行的。 In normal subjects without neurological disorders, cold air irrigation in the right ear induced vertiginous sensation, and significant activation was observed in the left insula, left inferior parietal lobule (BA40), left inferior occipital gyrus (BA19/37 ; V5), right precuneus (BA7), right supplementary motor area (BA6 ; SMA), right precentral gyrus (BA11) and左小脑半球。正常受试者中的小场左场光动动力学刺激激活了左主视觉皮层（BA17; V1），双侧中部枕骨健身房（BA19; V5），双侧前神经节（BA7），左后内度回去（BA4）和左海马。在涉及岛群，下顶叶和SMA的皮质网络中，可以处理垂直感觉的感知，而V5和Precuneus可能与前庭和光（光（Optookinetic Systems）共同的眼睛运动有关。另一方面，患有眩晕患者的光动力学刺激显着激活了左V1，左王回（BA18 / 19; v5），左SMA，左中膜（BA4），右侧胰岛 /下半部岛 /下部的额叶室，右侧侧叶（BA40），左侧cuud（ba40），左内cud teper1，左内孔（BA40），左内孔（Ba40）近中间孔（Ba40）近中间。皮质，SMA和基底神经节未包括在具有相同刺激的正常受试者中。这些结果表明，绝缘叶和下顶叶可能在垂直感觉的皮质加工中起重要作用，可用于客观评估眩晕及其治疗效果。