Molecular mechanism and regulation of assembly and remodeling of proteins
Molecular mechanism and regulation of assembly and remodeling of proteins
批准号:
20227004
负责人:
ARAKI Hiroyuki
金额:
$127.88万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008-05-12 至 2013-03-31
中文摘要
许多蛋白质在DNA复制起点组装并形成复合体。这些复合物随后被改造以启动DNA复制。本研究新鉴定了出芽酵母的pre-LC和Sld3-Sld7蛋白复合物。这些复合物招募两种复制因子Cdc45和GINS来起始并将复制解旋酶Mcm2-7改造成活性形式,将双链DNA解绕成单链DNA进行DNA复制。
英文摘要
Many proteins assemble and form complexes at DNA replication origins. The complexes are subsequently remodeled to initiate DNA replication. This study newly identified the pre-LC and the Sld3-Sld7 protein complexes of budding yeast. These complexes recruit two replication factors, Cdc45 and GINS to origins and remodel replicative helicase, Mcm2-7 to an active form, which unwinds double-stranded DNA to single-stranded DNA to perform DNA replication.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1128/mcb.00431-13
发表时间:
2013-05
期刊:
Molecular and Cellular Biology
影响因子:
5.3
作者:
[S. Tanaka;Y. Komeda;Toshiko Umemori;Y. Kubota;H. Takisawa;H. Araki]
通讯作者:
S. Tanaka;Y. Komeda;Toshiko Umemori;Y. Kubota;H. Takisawa;H. Araki
Periodic expression of Sld2 is important for DNA replication and genome integrity
Sld2 的周期性表达对于 DNA 复制和基因组完整性很重要
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Okabe M, Unno M, Harigae H, Kaku M, Okitsu Y, Sasaki T, Mizuno T, Shiiba K, Takanaga H, Terasaki T, Matsuno S, Sasaki I, Ito S, Abe T, Seiji Tanaka]
通讯作者:
Seiji Tanaka
染色体DNAの複製開始期に形成されるタンパク質複合体の生化学的解析
染色体 DNA 复制起始阶段形成的蛋白质复合物的生化分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[正井 久雄, 松本 清治, 平井和之]
通讯作者:
平井和之
真核細胞染色体DNA複製開始反応とCDKによる制御
真核染色体DNA复制起始反应及CDK的调控
DOI:
--
发表时间:
2008
期刊:
細胞工学 27
影响因子:
--
作者:
[Yoshizawa-Sugata, N., Ishii, A., Taniyama, C., Matsui, E., Arai, K., Masai, H., 荒木弘之, 荒木弘之]
通讯作者:
荒木弘之
Origin Association of Sld3, Sld7, and Cdc45Proteins Is a Key Step for Determination of Origin-Firing Timing
Sld3、Sld7 和 Cdc45 蛋白质的起源关联是确定起源激发时间的关键步骤
DOI:
--
发表时间:
2011
期刊:
Current Biol
影响因子:
--
作者:
[Tanaka S., Nakato R., Katou Y., Shirahige K., Araki H.]
通讯作者:
Araki H.
共 69 条
Development of thrust protection method for buried pipe using gabion
-
批准号:17K14723
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2017
-
负责人:ARAKI Hiroyuki
-
依托单位:
Development of biochemical and fine structural analyses methods for higher order chromosome structure
-
批准号:26650010
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2014
-
负责人:ARAKI Hiroyuki
-
依托单位:
Molecular mechanism of the initiation in eukaryotic chromosomal DNA replication
-
批准号:25251005
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$29.95万
-
财政年份:2013
-
负责人:ARAKI Hiroyuki
-
依托单位:
Development of phosphorus recovery system by using zeolite and hydrotalcite are used and conjugative regeneration of adsorbents
-
批准号:23560646
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:ARAKI Hiroyuki
-
依托单位:
Regulatory mechanism of replication complex formation and relationship between the complex, checkpoints and cell division
-
批准号:17080008
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$51.97万
-
财政年份:2005
-
负责人:ARAKI Hiroyuki
-
依托单位:
Molecular mechanism of assembly of replication proteins at replication origins in eukaryotes
-
批准号:15207012
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$31.53万
-
财政年份:2003
-
负责人:ARAKI Hiroyuki
-
依托单位:
Loading mechanism of DNA polymerases to replication origin
-
批准号:11694331
-
项目类别:Grant-in-Aid for Scientific Research (A).
-
资助金额:$5.25万
-
财政年份:1999
-
负责人:ARAKI Hiroyuki
-
依托单位:
海外基金