Research on pathology and protection of intracerebral hemorrhage with special reference to microglial functions
Research on pathology and protection of intracerebral hemorrhage with special reference to microglial functions
批准号:
20390026
负责人:
KATSUKI Hiroshi
金额:
$12.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Pathogenic mechanisms of intracerebral hemorrhage, a neurological disorder for which no effective drug therapies are available, were investigated in experimental animal models. Potential therapeutic effects of drugs that regulate functions of microglia, brain-resident immune cell population were also investigated. Obtained results have revealed that excessively activated microglia contribute to brain tissue damage following intracerebral hemorrhage, and that several low-molecular-weight compounds such as synthetic retinoids can produce therapeutic effects.
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Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures
长期尼古丁治疗可抑制皮质纹状体切片培养物中凝血酶的神经毒性和小胶质细胞激活
DOI:
--
发表时间:
2009
期刊:
Eur.J.Pharmacol. 602
影响因子:
--
作者:
[Ohnishi, M., Katsuki, H., Takagi, M., Kume, T., Akaike, A.]
通讯作者:
A.
RARアゴニストAm80による中脳BDNF発現増大に関わるシグナル伝達機序
RAR激动剂Am80增加中脑BDNF表达的信号转导机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[松下英明, 他, 遠藤玉夫, Daisuke Ogasawara, 藤田美歌子, 香月博志(代表者)]
通讯作者:
香月博志(代表者)
ラット中脳組織培養におけるtert-Buttylhydroquinoneのグルタチオンを介するドパミンニューロン保護効果
叔丁基氢醌对大鼠中脑组织培养中谷胱甘肽介导的多巴胺神经元的保护作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yuri Miura, Yoko Sakurai, Masato Hayakawa, Yukiko Shimada, Hans Zempel, Yuji Sato, Shin-ichi Hisanaga, Tamao Endo, 佐藤幸恵(代表者)]
通讯作者:
佐藤幸恵(代表者)
Nitric oxide signaling in protection of midbrain dopaminergic neurons.
一氧化氮信号传导保护中脑多巴胺能神经元。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[鈴木良明, その他, Katsuki H]
通讯作者:
Katsuki H
抗MUC1抗体によるMUC1の細胞取込みは、EGFRの局在変化と脱感作を誘導する
抗 MUC1 抗体对 MUC1 的细胞摄取诱导 EGFR 定位变化和脱敏
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[中山英樹(代表者)]
通讯作者:
中山英樹(代表者)
共 73 条
Investigations of the effects of supplementation of lipophilic vitamins aiming to improve prognosis of intracerebral hemorrhage
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批准号:20H04126
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.32万
-
财政年份:2020
-
负责人:KATSUKI Hiroshi
-
依托单位:
Novel system of pharmacological evaluation for the development of neuroprotective drugs based on the regulation of neutrophil phenotypes
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批准号:16K15204
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2016
-
负责人:KATSUKI Hiroshi
-
依托单位:
Establishment of assay system for drugs that regulate microglia via transcription factors
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批准号:26670036
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2014
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负责人:KATSUKI Hiroshi
-
依托单位:
Low molecular weight compounds that direct microglia toward alternative activation
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批准号:24659118
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
-
负责人:KATSUKI Hiroshi
-
依托单位:
Mechanisms and Prevention of Neurodegeneration via Microglial Activation in the Nigro-Striatal System
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批准号:18590052
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.55万
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财政年份:2006
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负责人:KATSUKI Hiroshi
-
依托单位:
Elucidation of multiple actions of reactive nitrogen species in degeneration of midbrain dopaminergic neurons
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批准号:16590048
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2004
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负责人:KATSUKI Hiroshi
-
依托单位:
Analysis of the mechanisims of protection of midbrain dopaminergic neurons by the innervation target with the usage of slice culture preparation
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批准号:12672110
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2000
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负责人:KATSUKI Hiroshi
-
依托单位:
Study on Neurotoxicity of Lidocaine
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批准号:10671426
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:1998
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负责人:KATSUKI Hiroshi
-
依托单位:
THE RELATIONSHIP OF TACHYPHYLAXIS IN EPIDURAL ANESTHESIA AND CSF pH CHANGE
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批准号:07671673
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:KATSUKI Hiroshi
-
依托单位:
海外基金