Role of nerve growth factor (NGF) in muscular pain

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To clarify the peripheral mechanism of muscular mechanical hyperalgesia, we analyzed roles of nerve growth factor (NGF) produced in the muscle in a few muscular pain models. We demonstrated that delayed onset muscle soreness was a result of sensitization of thin-fiber receptors by NGF that was up-regulated in the muscle after activation of B2 bradykinin receptors during exercise. We also demonstrated that NGF was not involved in muscular mechanical hyperalgesia in the repeated cold stress model, whereas it was involved in the spinal nerve ligation/cut model.