Growth factor and extracellular matrix in neural reconstruction

点击翻译按钮获取中文摘要

Axonal regeneration/sprouting hardly occur after neuronal injuries, mainly due to induction of inhibitory factors. Chondroitin sulfate is one of most well-known inhibitory factors. We found that keratan sulfate inhibits axonal regeneration/sprouting, and its inhibitory activity is as strong as that of chondroitin sulfate. For the inhibition, all the components of proteoglycans(i. e., keratan sulfate, chondroitin sulfate, core protein) are required. Our data suggest that an appropriate presentation of keratan sulfate and chondroitin sulfate by the core protein is important, and these sugar chains may be read by receptor(s) on neurons.