Identification of molecular targets for lung adenocarcinoma treatment through proteome analysis of phospholyrated kinases

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Phospholyration of protein is important in signal transduction. We screened phospholyrated proteins in lung adenocarcinoma cell by using mass spectrometry to identify molecular targets for lung cancer treatment. Some proteins, including GFRF1/p190 A RhoGAP, were strongly controlled by EGFR protein. Functional analysis revealed that GFRF1/p190 A RhoGAP protein controls lung cancer cell proliferation through regulating MEK/ERK pathway. This protein could be a candidate of molecular treatment of lung adenocarcinoma.