Enhancement of bone healing during distraction osteogenesis

牵引成骨过程中增强骨愈合

• 批准号: 20390401
• 负责人: YASUI Natsuo
• 金额: $ 12.65万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390401/
• 关键词: 仮骨延長; 骨成長因子; 持続投与; distraction; osteogenesis; osteoenesis

Rabbit tibial lengthening was achieved to examine the effect of local infusion of the growth factors and bisphosphonate into the lengthened segment. When FGF-2 and bisphosphonate were infused simultaneously during consolidation phase, bone healing was dramatically enhanced. FGF-2 stimulated bone formation while bisphosphonate inhibited bone resorption. We believe this method is valid to shorten the treatment time of limb lengthening and is applicable in the clinical field as a new drug delivery system.

采用兔胫骨延长术，观察局部注射生长因子和双磷酸盐对延长段的影响。当在固位期同时注入成纤维细胞生长因子-2和双磷酸盐时，骨愈合显著增强。成纤维细胞生长因子-2促进骨形成，双磷酸盐抑制骨吸收。我们认为这种方法能有效地缩短肢体延长术的治疗时间，作为一种新的给药系统，可以应用于临床。

项目成果

Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

• DOI: 10.1136/ard.2008.104315
• 发表时间: 2010-02-01
• 期刊: ANNALS OF THE RHEUMATIC DISEASES
• 影响因子: 27.4
• 作者: Nishimoto, K.;Kochi, Y.;Momohara, S.
• 通讯作者: Momohara, S.

Association study of TRAF1-C5 polymorphisms with susceptibility to the umatoid arthritis and systemic lupus erythematosus in Japanese.

TRAF1-C5 多态性与日本人类瘤样关节炎和系统性红斑狼疮易感性的关联研究。

• 发表时间: 2010
• 期刊: Ann Rheum Dis
• 影响因子: 27.4
• 作者: Nishimoto K;et al.
• 通讯作者: et al.

Enhanced bone healing by local infusion of FGF-2 and bisphosphonate during distraction osteogenesis

牵张成骨过程中局部输注 FGF-2 和双磷酸盐可增强骨愈合

• 发表时间: 2010
• 作者: Yasui N;et al.
• 通讯作者: et al.

骨格筋の特性が脚延長への適応に与える影響

骨骼肌特性对腿部延长适应的影响

• 发表时间: 2009
• 作者: 杉安謙仁朗;南野勝彦;吉川秀樹;名井陽;Saito A;小笠原邦昭;和田卓郎;高橋光彦
• 通讯作者: 高橋光彦

ビスホスホネートによる仮骨形成促進

双膦酸盐促进愈伤组织形成

• 发表时间: 2009
• 作者: 高橋光彦;Aziz Abbaspour;高田信二郎;西良浩一;松井好人;川崎賀照;油形公則;乾亜美;安井夏生
• 通讯作者: 安井夏生