The basic research for elucidation of molecular mechanism of the prostate cancer recurrence and the treatment strategy construction

1.肾上腺雄激素DHEA对前列腺癌的复发有重要作用。前列腺癌基质细胞和前列腺癌细胞通过从DHEA合成T和DHT来协同激活雄激素受体。2.曲尼司特抑制激素难治性前列腺癌细胞增殖并抑制TGF-β相关的成骨细胞变化。3.我们鉴定了与紫杉醇耐药相关的重要基因之一CTEN。CTEN表达可恢复紫杉醇耐药。

1. Adrenal androgen, DHEA, is important for recurrence of prostate cancer. Prostate cancer stromal cells and prostate cancer cells coordinately activate the androgen receptor through synthesis of T and DHT from DHEA. 2. Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses TGF-β-associated osteoblastic changes. 3. We identified CTEN, one of important genes that is associated with paclitaxel resistance. Expression of CTEN recovered paclitacel-resistance.