Characteristics of pulmonary circulation in high-altitude active animals-Biomolecular study focusing on the central role of Rho-kinase
Characteristics of pulmonary circulation in high-altitude active animals-Biomolecular study focusing on the central role of Rho-kinase
批准号:
20406021
负责人:
ISHIZAKI Takeshi
金额:
$10.57万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011
中文摘要
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英文摘要
Despite in the hypoxic air circumstance, yak, a high-altitude living animal, has never developed high-altitude pulmonary hypertension(HAPH). The reason behind it is that a Rho-kinase, an essential enzyme of maintaining of vascular tone is not activated in the pulmonary vessels. There is no remodeling of pulmonary arterial wall in yak. On the contrary, a bull or Kyrgyzstan people who are living at high-altitude and having HAPH have augmented activity of Rho-kinase.
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Effects of Rho-kinase inhibitor fasudil on pulmonary arterial pressure in highlanders with high altitude pulmonary hypertension. (Double-blind placebo-controlled study)
Rho激酶抑制剂法舒地尔对高原肺动脉高压患者肺动脉压的影响
DOI:
--
发表时间:
2009
期刊:
Eur Respir J 34
影响因子:
--
作者:
[Kei Uchizawa, et al., Baktybek Kojonazarov]
通讯作者:
Baktybek Kojonazarov
Pulmonary hypertension in high-altitude living animals and people in Kyrgyzstan
吉尔吉斯斯坦高海拔活体动物和人的肺动脉高压
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Funayama A, Maruyama S, Yamazaki M, Al-Eryani K, Shingaki S, Saito C, Cheng J, Saku T., A.Aldashev]
通讯作者:
A.Aldashev
Effects of Rho-kinase inhibitor fasudil on pulmonary arterial pressure in highlanders with high altitude pulmonary hypertension
Rho激酶抑制剂法舒地尔对高原肺动脉高压患者肺动脉压的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[B Kojonazarov, M Kasymbekova, M Wilkins, T Ishizaki, A Aldashev]
通讯作者:
A Aldashev
平成23年6月28日、松本大国際交流センターでの高山医学公開講義は中日新聞、松本市民タイムスに日本とキルギスタンの医学国際交流として記事が掲載された。
2011年6月28日,在松本大学国际交流中心举办的高山医学公开讲座,作为日本与吉尔吉斯斯坦之间的国际医学交流,被《中日新闻》和《松本市民时报》报道。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Bosentan reduces pulmonary artery pressure in high altitude residents High Altitude Medicine & Biology
波生坦可降低高原居民的肺动脉压力 High Altitude Medicine
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[B Kojonazarov, J Isakova, B Imanov, NSovkhozova, T Sooronbaev, T Ishizaki, A. Aldashev]
通讯作者:
A. Aldashev
共 8 条
Deterioration of building materials composing historical buildings and their protective measures
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批准号:20300291
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.15万
-
财政年份:2008
-
负责人:ISHIZAKI Takeshi
-
依托单位:
Assessment of COPD patients' information needs by using LINQ in Japan
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批准号:20592537
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.41万
-
财政年份:2008
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负责人:ISHIZAKI Takeshi
-
依托单位:
Molecular biological study of the role of Rho protein in hypoxic air induced pulmonary hypertension
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批准号:18590842
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.53万
-
财政年份:2006
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负责人:ISHIZAKI Takeshi
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依托单位:
Study on the conservation of Tumulus and Cave-effect of water and its protective measures-
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批准号:16300289
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.34万
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财政年份:2004
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负责人:ISHIZAKI Takeshi
-
依托单位:
Genomic characteristics of pulmonary circulation in high-altitude living animal
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批准号:16406026
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.06万
-
财政年份:2004
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负责人:ISHIZAKI Takeshi
-
依托单位:
Molecular biological study of cytotoxicity due to leukotoxins and their metabolites
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批准号:12470135
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.17万
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财政年份:2000
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负责人:ISHIZAKI Takeshi
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依托单位:
Study on deteriorarion mechanism and protective measures of historical stone monuments
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批准号:11694184
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.1万
-
财政年份:1999
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负责人:ISHIZAKI Takeshi
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依托单位:
Study on development of protective measures of historical remains and stone monuments under outside environment
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批准号:11558009
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.82万
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财政年份:1999
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负责人:ISHIZAKI Takeshi
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依托单位:
Study on physical properties of materials related to the deterioration of stone monuments and brick buildings.
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批准号:11650605
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
-
负责人:ISHIZAKI Takeshi
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依托单位:
Molecular biological study of leukotoxin and its diol-induced cell activation and injury -experimental model of ARDS-
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批准号:10670536
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1998
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负责人:ISHIZAKI Takeshi
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依托单位:
Study of Frost Weathering Mechanism of Porous Materials and its Protective Measures.
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批准号:09650615
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.73万
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财政年份:1997
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负责人:ISHIZAKI Takeshi
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依托单位:
EXPERIMENTAL STUDY OF METHANE HYDRATE FORMATION AND DECONPOSITION IN FROZEN SOILS
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批准号:07680597
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:ISHIZAKI Takeshi
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依托单位:
The role of endogenous endothelin (receptor) in injured lung.
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批准号:06670605
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1994
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负责人:ISHIZAKI Takeshi
-
依托单位:
Experimental study of frost heave mechanism
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批准号:05680353
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
-
财政年份:1993
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负责人:ISHIZAKI Takeshi
-
依托单位:
The effect of cytochrome P450 (metabolites) on pulmonary vascular tone
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批准号:02670339
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
-
财政年份:1990
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负责人:ISHIZAKI Takeshi
-
依托单位:
海外基金