Analys is of exocytotic mechanism of BDNF from astrocytes.
Analys is of exocytotic mechanism of BDNF from astrocytes.
批准号:
20500291
负责人:
ITAKURA Makoto
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The brain are made up of many cells, including neurons and glial cells. Astrocytes, a type of glial cells release various bioactive substances via Ca(2+)-and SNARE-dependent exocytosis. In the present study, we revealed that potent protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) treatment suppressed exogenously expressed human growth hormone release from cultured astrocytes. Moreover, PMA treatment induced the phosphorylation of synaptosomal-associated protein of 23 kDa on Ser(95), Ser(120), and Ser(160).
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M. Identification of PKC-dependent phosphorylation sites of SNAP-23inclonalglia cells
M. SNAP-23inclonalglia细胞PKC依赖性磷酸化位点的鉴定
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yasuda, K., Itakura, M., Nagata, E., Yamamori, S., Ihara, H., Takahashi]
通讯作者:
Takahashi
Identification of PKC-dependent phosphorylation sites of SNAP-23 in clonal glia cells
克隆神经胶质细胞中 SNAP-23 PKC 依赖性磷酸化位点的鉴定
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[K Yasuda, M ITakura, E Nagata, S Yamamori, H Ihara, M Takahashi]
通讯作者:
M Takahashi
M. Phorbol 12-myristate 13-acetate suppresses Cat+-dependent exocytotic release from rat astroglial cells
M.佛波醇 12-肉豆蔻酸酯 13-乙酸酯抑制大鼠星形胶质细胞 Cat 依赖性胞吐释放
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yasuda, K., Itakura, M., Aoyagi, K., Sugaya, T., Yamamori, S., Takahashi]
通讯作者:
Takahashi
M. PKC-dependent inhibition of CA2+-dependent exocytosis from astrocytes
M.星形胶质细胞 CA2 依赖性胞吐作用的 PKC 依赖性抑制
DOI:
--
发表时间:
2011
期刊:
Glia 59
影响因子:
--
作者:
[Yasuda, K., Itakura, M., Aoyagi, K., Sugaya, T., Nagata, E., Ihara, H., Takahashi]
通讯作者:
Takahashi
Characterization of BDNF expression and anxiety-related behavior in pilocarpine model mice.
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批准号:24500446
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:ITAKURA Makoto
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依托单位:
海外基金