Development of environmentally benign synthesis towards new biologically active substance

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Anodic oxidation of halogenated phenols, which was an efficient synthetic protocol of diaryl ethers shared by isodityrosine natural products, enabled optimization of cyclization reaction towards eurypamide, synthesis of diarylheptanolides, and methylthalibrine. Electrochemically generated hypervalent iodine oxidant was utilized for a synthesis of quinolinone derivatives, some of which were intermediates of tetrahydropyrroloiminoquinone alkaloids. Oxidation of aminodiaryls with the same oxidant provided carbazoles. Generation of methoxy radicals by BDD electrode in methanol solution was assessed, and reaction mechanism by this radical was discussed in neolignan synthesis.