Synthesis of biologically important molecules by means of elencrochemical procedures

一种新的合成方法通过使用环境友好的电有机化学提供了具有生物重要性的有机分子。采用含硼金刚石电极在甲醇溶液中的阳极氧化活性物种为甲氧基，并将该电极应用于有机合成，合成了几种新木脂素类化合物。此外，还通过连续的电化学反应合成了几种生物活性物质的核心二元醚部分。在电生酸存在下，通过极稳定的糖原酸酯与适当的苷元反应，得到了一种新的糖苷化反应。如上所述，已经提出了利用电能的新的合成方法。

A new synthetic methodology provided biologically important organic molecules by using environmentally benign electroorganic chemistry. Active species of anodic oxidation in methanol solvent employing the boron-doped diamond electrode, was determined to be a methoxy radical, and application of this electrode to organic synthesis produced several new molecules involving new-type neolignans. In addition, the core diary ether moiety of several bioactive substances was synthesized by successive electrochemical reactions. A new glycosidation was developed by reactions of extremely stable sugar orthoesters with appropriate aglycons in the presence of electrogenerated acid. As mentioned above,new synthetic procedures using electric energy have been proposed.