Bioinorganic study of transition metal localization in brain by the use of nuclear probe detection method

核探针检测法研究过渡金属在脑内的生物无机定位

• 批准号: 20550059
• 负责人: AMANO Ryohei
• 金额: $ 3.24万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20550059/
• 关键词: 核; 放射化学; 脳内微量元素; 脳局在性; スペシエーション; タリウム; 放射性元素; 生物無機化学; MRIイメージ; 核プローブ

In this study, several information and data on the in-vivo-localization of transition metal in brain were obtained by the use of four different nuclear probe detection methods. Especially, using RI technique, we found that trace heavy Tl ion transfers directly from nose to brain bypassing BBB. Intranasal administration of other metal ions was also examined by multi-tracer method. On the bases of results, the usefulness of ^<201>TlCl in rhinological fields was proposed to our other related projects. In correlation of metal imaging and MRI technique, we examined the detection of Mn in brain and behavior of Gd-DTPA in kidney.

本研究利用四种不同的核探针检测方法，获得了过渡金属在脑内的活体定位信息和数据。特别是利用放射性同位素示踪技术，我们发现微量重铊离子可直接从鼻腔绕过血脑屏障进入大脑。用多示踪剂法对其他金属离子的鼻腔给药进行了研究。在此基础上，提出了~（131）<201>TlCl在植物学领域的应用，并对我们的其它相关项目提出了建议。通过金属显像与MRI技术的相关性，观察了脑内Mn的检测和肾脏内Gd-DTPA的行为。

项目成果

Odor detection ability and thallium-201 transport in the olfactory nerve of traumatic olfactory-impaired mice

• DOI: 10.1093/chemse/bjn030
• 发表时间: 2008-09-01
• 期刊: CHEMICAL SENSES
• 影响因子: 3.5
• 作者: Shiga, Hideaki;Kinoshita, Yayoi;Miwa, Takaki
• 通讯作者: Miwa, Takaki

Biological safety of nasalthallium-201 administration : a preclfinical study for olfacto-scintigraphy.

鼻铊 201 给药的生物安全性：嗅觉闪烁扫描的临床前研究。

• 发表时间: 2011
• 期刊: Journal of Radiation Research
• 影响因子: 2
• 作者: Washiyama;K.;Shiga;H.;Hirota;K.;Tsuchida;A.;Yamamoto;J.;Yagi;S.;Yoshizaki;T.;Furukawa;M.;AmanoR.;Miwa
• 通讯作者: Miwa

α線放出薬剤_227Th-EDTMPを用いた造骨性骨転移モデルラツトの治療

α射线发射药_227Th-EDTMP治疗成骨细胞骨转移模型大鼠

• 发表时间: 2010
• 作者: 鷲山幸信;谷内田拓也;佐藤伊佐務;山村朝雄;天野良平
• 通讯作者: 天野良平

Thallium transport and the evaluation of olfactory nerve connectivity between the nasal cavity and olfactory bulb

• DOI: 10.1093/chemse/bjm066
• 发表时间: 2008-01-01
• 期刊: CHEMICAL SENSES
• 影响因子: 3.5
• 作者: Kinoshita, Yayoi;Shiga, Hideaki;Miwa, Takaki
• 通讯作者: Miwa, Takaki

Assessment by thallium-201 of hindlimb muscle blood flow in rats during recovery after hindlimb unloading

铊201对大鼠后肢卸载后恢复过程中后肢肌肉血流的评估

• 发表时间: 2009
• 期刊: J.Phys.Ther.Sci. 48
• 作者: Inaoka P.T.;Amano R.;Tanaka S.;Tachino K.
• 通讯作者: Tachino K.