Mechanism and evolution of developmental robustness against perturbation of the BICOID morphogen in Drosophila embryo

果蝇胚胎中 BICOID 形态发生素扰动的发育鲁棒性机制和进化

• 批准号: 20570100
• 负责人: TAKANO Toshiyuki
• 金额: $ 2.83万
• 依托单位: National Institute of Genetics
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20570100/
• 关键词: 進化; 発生・分化; 頑健性; モルフォジェン; bicoid

The maternal effect gene bicoid (bcd) serves as a morphogen and establishes AP axis in Drosophila. Whereas increased dosage of bcd causes enlargement of prospective head region in early embryogenesis, the adults have normal head size. Excessive cell death contributes to reduce the expanded head region; however, nothing is known about what triggers cell death and what kinds of genes are involved in the repair. From genetic screening and microarray experiments, we identified a candidate gene responsible for the repair, which is also involved in the response to irradiation-induced DNA damage.

母本效应基因bicoid（bcd）在果蝇中作为形态发生因子并建立AP轴。在胚胎发育早期，增加bcd剂量可使预期的头部区域增大，而成体头部大小正常。过度的细胞死亡有助于减少扩展的头部区域;然而，对于是什么触发细胞死亡以及哪些基因参与修复，我们一无所知。通过基因筛选和微阵列实验，我们确定了一个负责修复的候选基因，该基因也参与了对辐射诱导的DNA损伤的反应。

项目成果

A new test for detecting ongoing selection

用于检测正在进行的选择的新测试

• 发表时间: 2008
• 期刊: Genetica 133
• 作者: Inomata N.;Itoh M.;Kondo R.;Ohshima M.;Inoue Y.;Takano-Shimizu T.
• 通讯作者: Takano-Shimizu T.

Hidden genetic variation in the ability of repair of fate map shift caused by 6 copies of bcd gene in a natural population.

自然群体中6个拷贝的bcd基因引起的命运图移修复能力的隐藏遗传变异。

• 发表时间: 2010
• 作者: Popp D;Narita A;Fujisawa T;Robinson RC.;田中健太郎
• 通讯作者: 田中健太郎

キイロショウジョウバエにおける遺伝的撹乱に対するロバストネスの解析

果蝇遗传扰动的鲁棒性分析

• 发表时间: 2010
• 作者: Morinaga;A.;et.al.;田中健太郎
• 通讯作者: 田中健太郎

Environmental stress-dependent effects of deletions encompassing Hsp70Ba on canalization and quantitative trait asymmetry in Drosophila melanogaster.

Hsp70Ba 缺失对果蝇管道化和数量性状不对称性的环境应激依赖性影响。

• 发表时间: 2011
• 期刊: PLoS ONE 6
• 作者: Takahashi K.H.;Daborn P.J.;Hoffmann A.A.;Takano-Shimizu T.
• 通讯作者: Takano-Shimizu T.

Enhanced fixation and preservation of a newly arisen duplicate gene by masking deleterious loss-of-function mutations.

• DOI: 10.1017/s0016672309000196
• 发表时间: 2009-08
• 期刊: Genetics research
• 影响因子: 1.5
• 作者: Kentaro M. Tanaka;K. R. Takahasi;T. Takano-Shimizu