Analysis of yeast Cch1, a homologue of animal voltage-gated calcium channel pore subunit, and its regulatory factor Mid1.
Analysis of yeast Cch1, a homologue of animal voltage-gated calcium channel pore subunit, and its regulatory factor Mid1.
批准号:
20570158
负责人:
IIDA Kazuko
金额:
$3.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Cch1 is a yeast homologue of the pore-forming α1 subunit of animal voltage-gated calcium channels (VGCC), and Mid1 is an essential component together with Cch1 for the high-affinity calcium uptake in yeast. We tried to detect electric currents through the Cch1/Mid1 channel expressed in cultured mammalian cells or in yeast spheroplasts by the patch-clump method. Mid1 is heavily N-glycosylated allover the length, and Mid1 has a cysteine-rich motif in the C-terminal region. These characteristics suggest that Mid1 is a functional homologue of the α_2/δsubunit of animal VGCCs.
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電位作動性カルシウムチャネルα1サブユニットS2-S3リンカーに保存されているGly残基の役割
电压门控钙通道 α1 亚基 S2-S3 连接子中保守甘氨酸残基的作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[滕金風, 中瀬古(泉)寛子, 飯田和子, 小島至, 赤羽悟美, 飯田秀利]
通讯作者:
飯田秀利
カルシウム透過性機械受容チャネルの構造と機能
钙渗透性机械敏感通道的结构和功能
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[飯田秀利, 中野正貴, 原茂恵美子, 今村朋美, 飯田和子, 重松秀樹, 永山國昭]
通讯作者:
永山國昭
Ion-channel blocker sensitivity of voltage-gated calcium-channel homologue Cch1 in Saccharomyces cerevisuae.
酿酒酵母中电压门控钙通道同源物 Cch1 的离子通道阻滞剂敏感性。
DOI:
--
发表时间:
2008
期刊:
Microbiology 154
影响因子:
--
作者:
[Teng J., Goto R., Iida K., Kojima I., Iida H.]
通讯作者:
Iida H.
Role of glycine residues highly conserved in the domain I/II S2-S3 linkers of voltage-gated calcium channel α_1 subunits.
电压门控钙通道 α_1 亚基的 I/II 域 S2-S3 连接子中高度保守的甘氨酸残基的作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Teng J, et al.]
通讯作者:
et al.
MCA1 and MCA2 that mediate Ca^<2+> uptake have distinct and overlapping roles in Arabitopsis thaliana.
介导Ca^2吸收的MCA1和MCA2在拟南芥中具有不同且重叠的作用。
DOI:
--
发表时间:
2010
期刊:
Plant Physiol. 152
影响因子:
--
作者:
[Yamanaka T., Nakagawa Y., Mori K., Nakano M., Imamura T., Kataoka H., Terashima A., Iida K., Kojima I., Katagiri T., Shinozaki K., Iida H.]
通讯作者:
Iida H.
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Functions of cofilin, an actin-regulating protein
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批准号:09101002
-
项目类别:Grant-in-Aid for Specially Promoted Research
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资助金额:$131.84万
-
财政年份:1997
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负责人:IIDA Kazuko
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依托单位:
Molecular genetic analysis of factors which interact with an actin-binding protein cofilin of S.cerevisiae.
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批准号:07680786
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:IIDA Kazuko
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依托单位:
Molecular genetic analysis of the in vivo function of a low molecular weight actin-binding protein, cofilin, of S.cerevisiae.
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批准号:04833029
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1992
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负责人:IIDA Kazuko
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依托单位:
海外基金