Analysis of molecular mechanisms of endocytosis in C.elegans development

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We analyzed the rme mutants which show defects in yolk uptake by oocytes in C.elegans and identified novel rme genes conserved from the worm to human. We found that the rme-3 gene encodes clathrin. We also revealed that RME-4 functions on coated pits and/or vesicles to recruit small GTPase RAB-35, which in turn functions in the endosomes to promote receptor recycling. We further identified a candidate for the Rab35 effector molecule and examined its functions in endocytosis.