The role of endoplasmic reticulum (ER) stress in non-alcoholic steatohepatitis

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The role of endoplasmic reticulum (ER) stress in nonalcoholic steatohepatitis has not been fully elucidated. Because CHOP is one of the ER stress-related molecules, we compared CHOP knock out (KO) mice and wild type (WT) mice in steatohepatitis mice model using a methionine-choline (MCD) deficient diet. Steatosis and neutrophil infiltration, and apoptosis in liver tissue were significantly attenuated in KO mice compared with WT mice at 1 week after the administration of MCD diet. But these significant differences were transient. The time to peak level of the expression of PPAR γ was different between KO mice and WT mice. This may be one of the causes of the difference of pathophysiologic change between KO mice and WT mice.