The role of endoplasmic reticulum (ER) stress in non-alcoholic steatohepatitis

内质网（ER）应激在非酒精性脂肪性肝炎中的作用

• 批准号: 20590758
• 负责人: SATO Ken
• 金额: $ 3万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590758/
• 关键词: 発現制御; ストレス; シグナル伝達; 遺伝子; 病理学

The role of endoplasmic reticulum (ER) stress in nonalcoholic steatohepatitis has not been fully elucidated. Because CHOP is one of the ER stress-related molecules, we compared CHOP knock out (KO) mice and wild type (WT) mice in steatohepatitis mice model using a methionine-choline (MCD) deficient diet. Steatosis and neutrophil infiltration, and apoptosis in liver tissue were significantly attenuated in KO mice compared with WT mice at 1 week after the administration of MCD diet. But these significant differences were transient. The time to peak level of the expression of PPAR γ was different between KO mice and WT mice. This may be one of the causes of the difference of pathophysiologic change between KO mice and WT mice.

内质网（ER）应激在非酒精性脂肪性肝炎中的作用尚未完全阐明。由于CHOP是ER应激相关分子之一，我们在脂肪性肝炎小鼠模型中使用蛋氨酸胆碱（MCD）缺乏饮食比较了CHOP敲除（KO）小鼠和野生型（WT）小鼠。与WT小鼠相比，给予MCD饲料后1周，KO小鼠肝组织中的脂肪变性和中性粒细胞浸润以及细胞凋亡显著减弱。但这些显著差异是短暂的。KO小鼠和WT小鼠的PPAR γ表达达峰时间不同。这可能是KO小鼠与WT小鼠病理生理变化差异的原因之一。

项目成果

Werner syndrome as a possible cause of non-alcoholic steatohepatitis.

沃纳综合征是非酒精性脂肪性肝炎的可能原因。

• 发表时间: 2009
• 期刊: J Clin Pathol 62(11)
• 作者: Hashizume H;Sato K;Takagi H;Kanda D;Kashihara T;Kiso S;Mori M.
• 通讯作者: Mori M.

Transforming growth factor-α attenuates hepatic fibrosis: possible involvement of matrix metalloproteinase-1

• DOI: 10.1111/j.1478-3231.2011.02475.x
• 发表时间: 2011-04-01
• 期刊: LIVER INTERNATIONAL
• 影响因子: 6.7
• 作者: Ohyama, Tatsuya;Yamazaki, Yuichi;Mori, Masatomo
• 通讯作者: Mori, Masatomo