Activation balance of nuclear receptors ERα and CAR regulates hepatic lipid metabolism
Activation balance of nuclear receptors ERα and CAR regulates hepatic lipid metabolism
批准号:
20580318
负责人:
YAMAMOTO Yukio
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The underlying molecular mechanism of the sex difference in lipid metabolism remains largely unknown. We investigate the roles of hepatic nuclear receptors : ERα (Estrogen Receptor α), which is an authentic estrogen receptor, and LXR (Liver X Receptor) and CAR(Constitutive Androstane/Active Receptor), which are regulators of hepatic lipid metabolism. The transcriptional crosstalk between LXR, CAR, and ERα may explain the suppression mechanism of lipid synthesis by estrogens.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1161/atvbaha.108.171736
发表时间:
2008-12-01
期刊:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
影响因子:
8.7
作者:
[Yamada, Hideto, Yoshida, Masayuki, Ogawa, Yoshihiro]
通讯作者:
Ogawa, Yoshihiro
Estrogen Receptor a Mediates 17a-Ethynylestradiol-Causing Hepatotoxicity
雌激素受体 a 介导 17a-乙炔雌二醇引起的肝毒性
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[H. Yamada, et al., 建本秀樹, 楠比呂志, 中村 和美, 山本幸男]
通讯作者:
山本幸男
Nuclear receptor CAR represses TNFa-Induced cell death by interacting with the anti-apoptotic GADD45B
核受体 CAR 通过与抗凋亡 GADD45B 相互作用抑制 TNFa 诱导的细胞死亡
DOI:
--
发表时间:
2010
期刊:
PLoS One
影响因子:
3.7
作者:
[Y.Yamamoto, et al.]
通讯作者:
et al.
The anti-apoptotic factor GADD45B regulates the nuclear receptor CAR-mediated transcription.
抗凋亡因子 GADD45B 调节核受体 CAR 介导的转录。
DOI:
--
发表时间:
2008
期刊:
Drug Metab Dispos. 36
影响因子:
--
作者:
[Yamamoto Y, Negishi M.]
通讯作者:
Negishi M.
Estrogen Receptor α(ERα)の活性化は肝内胆汁うっ滞を引き起こす
雌激素受体 α (ERα) 的激活导致肝内胆汁淤积
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yukio Yamamoto, Rick Moore, Frank Gonzalez, Kenneth Korach, Masahiko Negishi]
通讯作者:
Masahiko Negishi
共 9 条
Proteomic analysis of pain-regulated and amyloid components in cerebrospinal fluid of patients with rheumatoid arthritis
-
批准号:19591828
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:YAMAMOTO Yukio
-
依托单位:
Development of novel probes for single-molecule imaging of proteihs
-
批准号:19350084
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.65万
-
财政年份:2007
-
负责人:YAMAMOTO Yukio
-
依托单位:
Studies in a new pain control of spinorphin, an endogenous peptide, in rheumatoid arthritis
-
批准号:16591577
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:2004
-
负责人:YAMAMOTO Yukio
-
依托单位:
Studies in~a new pain control by spinorphin, an endogenous factor : Changes in level of spinorphin and dipeptidyl peptidase III in cerebrospinal fluid from patients with pain
-
批准号:14572172
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.56万
-
财政年份:2002
-
负责人:YAMAMOTO Yukio
-
依托单位:
Synchrotron radiation effect on CIS thin films prepared by laser ablation for solar cell application
-
批准号:11680508
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:1999
-
负责人:YAMAMOTO Yukio
-
依托单位:
Studies in anti-inflammatory effect of spinorphin, an endogenous factor
-
批准号:10672168
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:1998
-
负责人:YAMAMOTO Yukio
-
依托单位:
A Scholary Research on the Shakyosho Documents of Shosoin
-
批准号:10410085
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$3.52万
-
财政年份:1998
-
负责人:YAMAMOTO Yukio
-
依托单位:
One-electron Reduction and Electron Transfer Reaction Controlled by Cyclodextrin Inclusion Complexation
-
批准号:05650826
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1993
-
负责人:YAMAMOTO Yukio
-
依托单位:
New Development of Enzyme Utilization in Organic Solvents
-
批准号:04806019
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1992
-
负责人:YAMAMOTO Yukio
-
依托单位:
Metabolism in root nodules and function of leghemoglobin
-
批准号:62490009
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$2.56万
-
财政年份:1987
-
负责人:YAMAMOTO Yukio
-
依托单位:
海外基金