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Activation balance of nuclear receptors ERα and CAR regulates hepatic lipid metabolism

Activation balance of nuclear receptors ERα and CAR regulates hepatic lipid metabolism
核受体ERα和CAR的激活平衡调节肝脏脂质代谢
批准号:
20580318
负责人:
YAMAMOTO Yukio
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
The underlying molecular mechanism of the sex difference in lipid metabolism remains largely unknown. We investigate the roles of hepatic nuclear receptors : ERα (Estrogen Receptor α), which is an authentic estrogen receptor, and LXR (Liver X Receptor) and CAR(Constitutive Androstane/Active Receptor), which are regulators of hepatic lipid metabolism. The transcriptional crosstalk between LXR, CAR, and ERα may explain the suppression mechanism of lipid synthesis by estrogens.
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DOI: 10.1161/atvbaha.108.171736
发表时间: 2008-12-01
期刊: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
影响因子: 8.7
作者: [Yamada, Hideto, Yoshida, Masayuki, Ogawa, Yoshihiro]
通讯作者: Ogawa, Yoshihiro
Estrogen Receptor a Mediates 17a-Ethynylestradiol-Causing Hepatotoxicity
雌激素受体 a 介导 17a-乙炔雌二醇引起的肝毒性
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [H. Yamada, et al., 建本秀樹, 楠比呂志, 中村 和美, 山本幸男]
通讯作者: 山本幸男
Nuclear receptor CAR represses TNFa-Induced cell death by interacting with the anti-apoptotic GADD45B
核受体 CAR 通过与抗凋亡 GADD45B 相互作用抑制 TNFa 诱导的细胞死亡
DOI: --
发表时间: 2010
期刊: PLoS One
影响因子: 3.7
作者: [Y.Yamamoto, et al.]
通讯作者: et al.
The anti-apoptotic factor GADD45B regulates the nuclear receptor CAR-mediated transcription.
抗凋亡因子 GADD45B 调节核受体 CAR 介导的转录。
DOI: --
发表时间: 2008
期刊: Drug Metab Dispos. 36
影响因子: --
作者: [Yamamoto Y, Negishi M.]
通讯作者: Negishi M.
9
    Proteomic analysis of pain-regulated and amyloid components in cerebrospinal fluid of patients with rheumatoid arthritis
    Development of novel probes for single-molecule imaging of proteihs
    • 批准号:
      19350084
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.65万
    • 财政年份:
      2007
    • 负责人:
      YAMAMOTO Yukio
    • 依托单位:
    Studies in a new pain control of spinorphin, an endogenous peptide, in rheumatoid arthritis
    Studies in~a new pain control by spinorphin, an endogenous factor : Changes in level of spinorphin and dipeptidyl peptidase III in cerebrospinal fluid from patients with pain
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