Age-dependant NO production and its regulation involved in the uterus and placenta of pregnant rat

观察了妊娠大鼠子宫内膜和胎盘组织中NO的产生及其调控。妊娠17.5天(GD17.5)和胎盘15.5天(GD17.5)子宫内膜和胎盘中NO水平分别达到峰值。这些NO的产生主要来自于诱导组织中的NO合成酶。在GD17.5上，NO产生的抑制剂通过典型的细胞凋亡信号在子宫内膜引起细胞凋亡，提示子宫内膜中的NO峰对于细胞存活和维持子宫形成是必不可少的。

NO production and its regulation involved in the uterine endometrium and placenta were examined in pregnant rat. NO productions level peak on gestational day 17.5 (GD17.5)and GD15.5 in the endometrium and placenta, respectively. These NO productions were mainly derived from induced NO synthase in the tissues. Inhibitor of NO production caused apoptosis through typical apoptotic signals in the endometriumu on GD17.5, suggesting that an NO peak in the endometrium is essential to cell survival and the maintenance of uterine formation.