Age-dependant NO production and its regulation involved in the uterus and placenta of pregnant rat

妊娠大鼠子宫和胎盘的年龄依赖性NO产生及其调控

• 批准号: 20580329
• 负责人: TAKIZAWA Tatsuya
• 金额: $ 3.08万
• 依托单位: Azabu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20580329/
• 关键词: 動物; 発生・分化; スピントラップ・EPR; 生体分子; ラット

NO production and its regulation involved in the uterine endometrium and placenta were examined in pregnant rat. NO productions level peak on gestational day 17.5 (GD17.5)and GD15.5 in the endometrium and placenta, respectively. These NO productions were mainly derived from induced NO synthase in the tissues. Inhibitor of NO production caused apoptosis through typical apoptotic signals in the endometriumu on GD17.5, suggesting that an NO peak in the endometrium is essential to cell survival and the maintenance of uterine formation.

本实验观察了孕鼠子宫内膜和胎盘组织中NO的产生及其调节。NO在子宫内膜和胎盘中分别于妊娠第17.5天（GD17.5）和15.5天达到高峰。这些NO的产生主要来源于组织中的诱导型NO合酶。NO产生抑制剂通过典型的凋亡信号在GD17.5引起子宫内膜细胞凋亡，提示子宫内膜中的NO峰对于细胞存活和子宫形成的维持是必需的。

项目成果

Nitric Oxide Production and its Contribution to Hepatocyte Proliferation in Normal Juvenile Rats

• DOI: 10.1292/jvms.09-0551
• 发表时间: 2010-07-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Inukai, Naoto;Uchida, Mayuko;Takizawa, Tatsuya
• 通讯作者: Takizawa, Tatsuya

Apoptosis caused by an inhibitor of NO production in the decidua of rat from mid-gestation.

妊娠中期大鼠蜕膜中 NO 产生抑制剂引起的细胞凋亡。

• 发表时间: 2010
• 期刊: Exp.Bio.Med (Maywood) 235(4)
• 作者: Suzuki T.;Nagamatsu C.;Kushima T.;Miyakoshi R.;Tanaka K.;Morita H. Sakaue M.;Takizawa T.
• 通讯作者: Takizawa T.

ラット胎盤における血管新生因子に及ぼす一酸化窒素(NO)の役割

一氧化氮（NO）对大鼠胎盘血管生成因子的作用

• 发表时间: 2010
• 作者: 西村朋夏;久島貴広;鈴木武人;宮崎陽子;田中和明;滝沢達也
• 通讯作者: 滝沢達也

Gestational changes in production of NO and expression of NOS mRNA isoforms in the rat placenta.

• DOI: 10.1292/jvms.71.495
• 发表时间: 2009-04
• 期刊: The Journal of veterinary medical science
• 作者: Takehito Suzuki;Y. Ikeda;H. Yoshikawa;Kazuaki Tanaka;H. Morita;Masako Yamamoto;T. Takizawa

Apoptosis caused by an inhibitor of NO production in the decidua of rat from mid-gestation

NO生成抑制剂引起妊娠中期大鼠蜕膜细胞凋亡

• 发表时间: 2010
• 期刊: Exp.Bio.Med (Maywood)
• 作者: Suzuki T.;Nagamatsu C.;Kushima T.;Miyakoshi R.;Tanaka K.;Morita H.;Sakaue M.;Takizawa T.
• 通讯作者: Takizawa T.