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Structure and functions of polyamine transport proteins and NMDA receptors

Structure and functions of polyamine transport proteins and NMDA receptors
多胺转运蛋白和 NMDA 受体的结构和功能
批准号:
20590066
负责人:
KASHIWAGI Keiko
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Polyamines (putrescine, spermidine and spermine) play important roles in cell proliferation and differentiation. In this study, mechanism of polyamine transport and role of polyamines on NMDA receptor activities have been studied. As the results, a spermidine excretion system was newly identified and amino acid residues involved in the activities of polyamine uptake system were identified. Properties of regulatory (R) domains of NMDA receptor were characterized and regulatory sites by spermine in the channel region of NMDA receptor were identified.
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The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by sperimine.
N-甲基-D-天冬氨酸受体的孔区域对精胺的刺激和阻断有不同的影响。
DOI: --
发表时间: 2008
期刊: J. Pharmacol. Exp. Ther. 327
影响因子: --
作者: [Jin, L., et al.]
通讯作者: et al.
高度好熱菌及び大腸菌ポリアミン取り込み系PotABCDのポリアミン結合蛋白質PotDの基質認識
超嗜热菌多胺结合蛋白PotD与大肠杆菌多胺摄取系统PotABCD的底物识别
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [K.Takeuchi, T.Shin-Ya, K.Nishio, F.Ito, 吉沢佑基, 照井祐介, 野中元裕,Ma BY.,川嵜伸子,川嵜敏祐, 榛葉繁紀, 金井健]
通讯作者: 金井健
Isolation and biological characterization of an acrolein tolerant mutant of FM3A cells.
FM3A 细胞耐丙烯醛突变体的分离和生物学表征。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Nakamura, M.]
通讯作者: M.
ポリアミンにより合成促進されるribosome modulation factorの大腸菌生存率維持に果たす役割
多胺促进核糖体调节因子的合成,在维持大肠杆菌存活率中的作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Y Kawamori, K Nakagawa, T Okano, 他, Masumi A, 秋山真律子]
通讯作者: 秋山真律子
71
    Physiological role of polyamines and regulation of their cellular contents
    • 批准号:
      23590088
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2011
    • 负责人:
      KASHIWAGI Keiko
    • 依托单位:
    Molecular mechanism and physiological role of polyamine transport systems and NMDA receptors
    • 批准号:
      18590069
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.57万
    • 财政年份:
      2006
    • 负责人:
      KASHIWAGI Keiko
    • 依托单位:
    Structure and function of polyamine transport systems and NMDA receptors
    Cultural and Developmental Perspectives on Social Change and Family, Self and Gender
    • 批准号:
      15330143
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.74万
    • 财政年份:
      2003
    • 负责人:
      KASHIWAGI Keiko
    • 依托单位:
    海外基金