New synthetic peptide enhances plasminogen activation and thrombolysis
New synthetic peptide enhances plasminogen activation and thrombolysis
批准号:
20590222
负责人:
OKADA Kiyotaka
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
A new synthetic nonadecapeptide (SP) corresponding to Glu22-Leu40 of staphylokinase molecule bound to plasminogen (Plg) and enhanced the activation of Plg by Plg activator (PA). This binding was completely inhibited by synthetic peptide corresponding to C-terminal region of plasmin B-chain. SP binds to Glu-Plg, and induces structural changes of Glu-Plg. When SP was administrated in mouse thrombosis model, earlier recanalization was observed than in mice with vehicle administration. Thus, SP enhanced Plg activation and induced effective thrombolysis.
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Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.
纤溶酶原在小鼠海马、大脑皮层和下丘脑中的定位。
DOI:
--
发表时间:
2011
期刊:
Cell Tissue Res 343
影响因子:
--
作者:
[Taniguchi Y, Inoue N, Morita S, Nikaido Y, Nakashima T, Nagai N, Okada K, Matsuo O, Miyata S]
通讯作者:
Miyata S
Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.
纤溶酶原与从受损小鼠肝脏中分离出的肝细胞的结合以及肝细胞的非实质细胞依赖性增殖。
DOI:
--
发表时间:
2008
期刊:
Blood Coagulation and Fibrinolysis 19
影响因子:
--
作者:
[永井信夫, 松尾理, Li Y, Kanno Y, Hou Y, Kanno Y, Okada K]
通讯作者:
Okada K
DOI:
10.1097/mbc.0b013e328337b3dd
发表时间:
2010-04-01
期刊:
BLOOD COAGULATION & FIBRINOLYSIS
影响因子:
1.1
作者:
[Ishida,Chikako, Ueshima,Shigeru, Matsuo,Osamu]
通讯作者:
Matsuo,Osamu
アンギオテンシンII誘発性の血管障害に対するα2-antiplasminの関与
α2-抗纤溶酶参与血管紧张素 II 诱导的血管损伤
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shigefumi Yokota, Yoshio Shinozaki, Yoshitaka Oku, Yasumasa Okada, Yukihiko Yasui, 岡田清孝]
通讯作者:
岡田清孝
DOI:
10.1038/jid.2008.157
发表时间:
2008-12-01
期刊:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
影响因子:
6.5
作者:
[Kanno, Yosuke, Kaneiwa, Aki, Matsuno, Hiroyuki]
通讯作者:
Matsuno, Hiroyuki
共 19 条
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Molecular Mechanisms Controlling Embryo and Meristem Formation
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依托单位:
Analysis of fibrinolytic activation mechanism by staphylokinase in gene deficient mice
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Molecular Mechanism of Intercellular Signaling in Plant Organogenesis
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Molecular Genetic Study of Plant Organogenesis and Stimulus-Response Interactions Using Arabidopsis.
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