Analysis of disease-related genes involved in Rho family small GTPase signaling
Analysis of disease-related genes involved in Rho family small GTPase signaling
批准号:
20590308
负责人:
AMANO Mutsuki
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
This study aimed to identify and characterize the disease-related genes involved in Rho family small GTPase signaling pathways to understand the pathogenesis of cardiovascular diseases and mental disorders. We found that the SNP (Ala370Ser) within PH domain of ARHGAP9, which is a negative regulator of Rac, was associated with a significant risk of coronary artery spasm. The Ala370Ser polymorphism counteracted ARHGAP9-reduced cell migration, spreading and adhesion, suggesting that it results in a critical difference in ARHGAP9 function.
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DOI:
10.1002/cm.20472
发表时间:
2010-09
期刊:
CYTOSKELETON
影响因子:
2.9
作者:
[Amano, Mutsuki, Nakayama, Masanori, Kaibuchi, Kozo]
通讯作者:
Kaibuchi, Kozo
Roles of Rho/Rho-kinase in Cellular functions and Diseases
Rho/Rho 激酶在细胞功能和疾病中的作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Tsuchiya H, Shirai T, Morsy A, Sakayama K, Wada T, Kusuzaki K, Sugita T, Tomita K, 伊豫田拓也,岩本隆宏, Mutsuki Amano]
通讯作者:
Mutsuki Amano
Screening of Protein kinase Substrates by an Interactome Approach
通过相互作用组方法筛选蛋白激酶底物
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[曽根雅紀, 岡澤均, 鍋島陽一, 天野睦紀]
通讯作者:
天野睦紀
蛋白質間相互作用を利用したキナーゼ基質の網羅的解析
利用蛋白质-蛋白质相互作用综合分析激酶底物
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[曽根雅紀, 鍋島陽一, 岡澤均, 天野睦紀]
通讯作者:
天野睦紀
A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase.
DOI:
10.1371/journal.pone.0008704
发表时间:
2010-01-14
期刊:
PloS one
影响因子:
3.7
作者:
[Amano M, Tsumura Y, Taki K, Harada H, Mori K, Nishioka T, Kato K, Suzuki T, Nishioka Y, Iwamatsu A, Kaibuchi K]
通讯作者:
Kaibuchi K
共 16 条
Involvement of small GTPase Rho family signaling pathways in diseases.
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批准号:23590357
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2011
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负责人:AMANO Mutsuki
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依托单位:
Analysis of disease susceptibility genes on Rho family signaling molecules
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批准号:18590261
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:AMANO Mutsuki
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依托单位:
海外基金